Pressure-pain sensitivity and natural pain-blocking after a cold hand immersion in people with and without tennis elbow

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will measure pressure pain thresholds (PPT) at standardized sites near the elbow and wrist using a digital algometer and will use a cold‑pressor task (hand in ice water) to trigger conditioned pain modulation (CPM). PPT will be recorded at set time points before, during, and after the cold stimulus to map how pain sensitivity changes and how long any pain‑inhibiting effect lasts. The study will also examine PPT measurement reliability using intraclass correlation coefficients (ICC), standard error of measurement (SEM), and smallest detectable change (SDC). Testing takes place in the university physiotherapy clinic with coded data stored on institutional systems and repeated measures following a predefined protocol.

Why it matters

Who can join: the full rules

TE Group

Inclusion Criteria:

Patients with Tennis Elbow confirmed at initial assessment by the Primary Investigator (PI)

Unilateral elbow pain \> 6 weeks duration reproduced on at least two of the following tests:

* Palpation of the lateral epicondyle
* Isometric testing of the wrist extensors
* Middle finger extension test
* Passive stretch of wrist extensors
* Resisted hand gripping using a dynamometer
* Upper limb neurodynamic test-radial nerve bias (ULNDT-RN)

Exclusion Criteria:

* History of chronic pain conditions (e.g. fibromyalgia, irritable bowel
* syndrome, temporomandibular dysfunction, migraines)
* Neurological or sensory dysfunction (especially in the upper limbs)
* History of chronic musculoskeletal pain (e.g. arthritis, chronic low back
* pain)
* Contraindications to cold application (i.e. Reynaud's disease, diabetes)
* Current or long-term use of pain medication or anti-depressants

Healthy Group The asymptomatic group included adults (18-65 years) without pain (acute or chronic) at least 3 months before the experimental sessions.

Where it's running

• The Hashemite University, Department of Physical Therapy; Community Rehabilitation Center Clinics
  Zarqa, Zarqa Governorate, Jordan Recruiting

Study contacts

• Principal investigator: Ahmad Muhsen — The Hashemite University
• Study coordinator: Ahmad Muhsen, PhD
• Email: muhsen_a@hu.edu.jo
• Phone: +962788654656

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Morningness vs. eveningness and how quickly healthy adults recover after submaximal exercise

  This study tests whether people who prefer morning or evening are linked to how quickly healthy adults recover after a light-to-moderate workout.

  Recruiting Saglik Bilimleri Universitesi · Istanbul · NCT07833956

• Orally Taken TIX100 in Healthy Overweight/Obese Adults

  This study will test whether daily oral TIX100 is safe and well tolerated in healthy adults who are overweight or obese.

  Recruiting Phase 1 TIXiMED, Inc. · Chula Vista, California · NCT07675590

• YR001 Topical Ointment safety and PK in healthy Chinese adults

  This study tests whether YR001 ointment is safe and tolerable and how it behaves in the body after single and repeated applications in healthy Chinese adults, compared with a placebo.

  Recruiting Phase 1 Hangzhou Yirui Pharmaceutical Technology Co., Ltd · Langfang, Hebei · NCT07673458

• Does Yoga Style Affect Sleep and Heart Health in Adults with and without Insomnia

  This study tests whether two styles of yoga (vinyasa and gentle yoga) done in the evening can improve sleep and heart health in adults, including those with insomnia.

  Recruiting University of Central Florida · Orlando, Florida · NCT07638267

• Heavy slow-resistance wrist exercises and shoulder stabilization to reduce pain and improve grip in tennis elbow

  This test will compare six weeks of heavy slow-resistance wrist exercises against shoulder stabilization exercises to see which better reduces pain and improves grip and function in adults aged 30–50 with tennis elbow.

  Recruiting University of Faisalabad · Sādiqābād · NCT07576829

• Single-dose testing of JPH034 in healthy adults.

  This trial tests single ascending doses of the experimental drug JPH034 versus placebo in healthy adults aged 18–50 to see if the drug is safe, how the body handles it, and whether food affects absorption.

  Recruiting Phase 1 J-Pharma Co., Ltd. · Dilworth, Minnesota · NCT07534657

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.