Clinical trial Recruiting at 1 site Interventional Ages Any age to 90

Preserving the submandibular gland during neck dissection for oral cancer patients

Official title: Submandibular Gland Preservation During Neck Dissection for Oral Squamous Cell Carcinoma

Run by Peking University · NCT03385720 · Data updated 2026-11-12

This study tests if keeping the submandibular gland during surgery helps early-stage oral cancer patients live longer compared to those who have it removed.

More Oral Cancer trials

Quick facts

Study typeInterventional
AgesAny age to 90 Years
SexAll
Enrollment200 (estimated)
SponsorPeking University
Academic / other
Locations1 site (Beijing, Beijing Municipality)
StatusRecruiting
StartedDecember 5, 2017
Main results expectedDecember 2023
Study endsDecember 2030
Registry record updatedMarch 30, 2023
Trial IDNCT03385720 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients diagnosed with early-stage oral squamous cell carcinoma (T1N0 and T2N0).

Probably not a fit

Patients with cancer of the floor of the mouth will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of preserving the submandibular gland during neck dissection in patients with early-stage oral squamous cell carcinoma. Participants are randomly assigned to either an experimental group, where the gland is preserved, or a control group, where it is removed. The study aims to compare survival and mortality rates between the two groups to assess the benefits of gland preservation. The trial focuses on patients with primary oral cancer, specifically those classified as T1N0 and T2N0.

Why it matters

Potential benefit: If successful, this approach could improve patient outcomes by reducing complications associated with gland removal.

How similar studies have gone: While there may be studies on neck dissection techniques, this specific approach to gland preservation is relatively novel and has not been widely tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Primary oral squamous cell carcinoma of early stage (T1N0 and T2N0).

Exclusion Criteria:

Cancer of the floor of the mouth.

Where it's running

  • Peking University School of Stomatology
    Beijing, Beijing Municipality, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.