Preserving the sinus (Schneiderian) membrane to help bone regrow after upper-jaw removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a small case series in which surgeons preserved the Schneiderian (sinus) membrane while removing diseased portions of the maxilla in two female patients. The preserved membrane was left in situ to see whether it would support spontaneous bone formation in the postoperative defect. Patients were followed with serial CT scans to document new bone growth and were evaluated for complications such as oronasal fistula and empty nose syndrome as well as functional outcomes like chewing, swallowing, speech, and quality of life. The series focused on patients whose tumors did not invade the sinus cavity and who were unsuitable for or declined complex reconstructive flaps.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Maxillary lesions requiring resection of the jaw as diagnosed by imaging (CT) and pathology;
* CT shows the lesion only invades the maxilla without involving the maxillary sinus cavity;
* No nasal septum within the maxillary sinus cavity, with an intact and smooth sinus floor bone wall;
* No distant metastatic malignant tumors;
* American Society of Anesthesiologists (ASA) classification I-III, able to tolerate general anesthesia.

Exclusion Criteria:

* Lesions invading the maxillary sinus mucosa;
* Presence of septa or severe inflammation in the maxillary sinus;
* Previous history of head and neck radiotherapy;
* Coexisting immune system diseases or metabolic bone diseases;
* Pregnancy or breastfeeding;
* Any surgical contraindications;
* Mental illness or inability to comply with follow-up.

Where it's running

• The Second Hospital of Shanxi Medical University
  Shanxi, China Recruiting

Study contacts

• Study coordinator: Wenzhao Guan
• Email: guanwenzhao_111@163.com
• Phone: 13700542824

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.