Preoperative speech rehabilitation for patients with drug-resistant temporal epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with drug-resistant temporal lobe epilepsy who are candidates for neurosurgery. It aims to implement a specific speech rehabilitation program designed to improve cognitive functions, particularly lexical access and verbal memory, prior to surgical intervention. The approach is based on cognitive theories and models of neural plasticity, with the goal of enhancing cognitive reserve and potentially mitigating postoperative cognitive difficulties. Participants will undergo speech therapy assessments and interventions tailored to their needs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient 16 years of age and older,
2. Patient whose epileptogenic area involves the temporal structures of the hemisphere specialized for language,
3. Patient whose hemispheric specialization for language is known
4. Patient willing to undergo resective surgery such as anterior temporal lobectomy or resection in the temporal lobe involving the hippocampus and/or the baso-temporal language area and whose planned surgery date is compatible with the performance of the study,
5. Patient with a known NTB score
6. Patient who has signed an informed consent or patient whose parents or legal guardians have signed the informed consent (or a single parent or legal guardian if applicable)
7. Patient whose first language is French (1st language learned by the patient),
8. Patient declaring to be familiar with the use of a computer and having access to an internet connection from home
9. Patient affiliated or benefiting from a social security system.

Exclusion Criteria:

1. Patient with a speech disorder that may impair intelligibility and compromise the use of the interface;
2. Patient with an uncorrected hearing impairment,
3. Patients with a total intelligence quotient (IQ) \<70 (assessed in the context of care, in the year preceding the surgical procedure)
4. Patients who are pregnant, nursing, deprived of liberty, under guardianship or curatorship.

Where it's running

• Service EFSN - Hôpital Pellegrin
  Bordeaux, France Recruiting
• Service de Neurologie de l'Epilepsie - CHU Grenoble-Alpes
  Grenoble, France Recruiting
• Département de Neurophysiologie Clinique - Hôpital Roger Salengro - CHU Lille
  Lille, France Recruiting
• Service Epilptologie et Rythmologie Cérébrale
  Marseille, France Recruiting
• Service de Neurologie - Fondation ophtalmologique de Rothschild - Fondation Rothschild
  Paris, France Recruiting
• Service de Neurologie - Hôpitaux Universitaires, Hôpital de Hautepierre
  Strasbourg, France Recruiting

Study contacts

• Study coordinator: Veronique Sabadell
• Email: veronique.sabadell@ap-hm.fr
• Phone: 0491385298

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.