Preoperative rehabilitation for lung cancer surgery patients

Effects of Preoperative Rehabilitation in Patients Resected for Lung Cancer

This study tests if a home rehabilitation program can help lung cancer surgery patients with COPD recover better compared to just receiving chest physiotherapy.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 90 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Centre Jean Perrin (other)
• Locations: 6 sites (Clermont-Ferrand and 5 other locations)
• Trial ID: NCT03020251 on ClinicalTrials.gov

What this trial studies

This randomized controlled trial evaluates the effects of a preoperative rehabilitation program at home for patients undergoing lung cancer resection. Participants will be divided into two groups: one receiving only chest physiotherapy and the other receiving both chest physiotherapy and a structured rehabilitation program. The aim is to assess the impact of the rehabilitation on recovery and overall outcomes post-surgery. The study focuses on patients with chronic obstructive pulmonary disease (COPD) who are eligible for lung cancer surgery.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 diagnosed with lung cancer eligible for resection surgery and who have COPD stages 2-4.

Not a fit: Patients with early-stage COPD, contraindications for exercise, or those living alone may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could enhance recovery and improve surgical outcomes for lung cancer patients.

How similar studies have performed: Other studies have shown positive outcomes with preoperative rehabilitation in similar patient populations, suggesting potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

* Patients diagnosed for lung cancer (or highly suspicious for cancer tumor) eligible for resection surgery (lobectomy or pneumonectomy)
* Age \> 18 years
* Presence of Chronic Obstructive Pulmonary Disease (COPD) stages 2-4 of Gold (forced expiratory volume (FEV )/ forced vital capacity (FVC) \<70%, FEV \<80% of predicted) and Exertional dyspnea stage MMRC (Medical Research Council) \> 1
* Patients must provide written consent
* Member of social security scheme

Exclusion Criteria:

* Patients refusing to participate
* COPD stage 1 Gold (VEMS \>= 80% of the theoretical value)
* Presenting an operating contraindication during the initial maximal exercise test
* Presenting cardiac or vascular contraindication to achieve the readaptation program
* Patient living alone at home
* Patient with ventilatory assistance at home (oxygen therapy or noninvasive ventilation (NIV))
* With exercise hypoventilation (PaCO2 \>45 mmHg)
* Cognitive difficulty
* unable major
* pregnancy,
* patients deprived of liberty by a court or administrative decision

Where this trial is running

Clermont-Ferrand and 5 other locations

• CHU Clermont Ferrand, Gabriel Montpied, service de médecine du sport et explorations fonctionnelles, — Clermont-Ferrand, France (NOT_YET_RECRUITING)
• Centre de Recherche en Nutrition Humaine — Clermont-Ferrand, France (NOT_YET_RECRUITING)
• Centre Jean Perrin — Clermont-Ferrand, France (RECRUITING)
• CHU Grenoble, Hôpital Michallon — Grenoble, France (NOT_YET_RECRUITING)
• Hospices Civiles de Lyon, groupement hospitalier Est, Hopital Louis Pradel — Lyon, France (NOT_YET_RECRUITING)
• CHU Saint-Etienne, CHU Hopital Nord — Saint Etienne, France (NOT_YET_RECRUITING)

Study contacts

• Principal investigator: Marc FILAIRE, Pr — Centre Jean Perrin
• Study coordinator: Marc FILAIRE, Pr

Conditions: Lungcancer, preoperative rehabilitation program, chest physiotherapy, lung cancer resection