Preoperative pulmonary rehabilitation for smokers with lung nodules

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project involves a single-arm, non-masked intervention where participants who are current smokers with suspicious lung nodules will undergo pulmonary rehabilitation (PR) before lung cancer treatment. The study aims to assess the feasibility and acceptability of this prehabilitation approach, including smoking cessation support. Participants will be monitored for various outcomes such as fitness levels, respiratory symptoms, and surgical complications over a two-year period. The study will enroll approximately 20 participants from the University of Vermont Medical Center, focusing on those who are eligible for lung cancer treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Lung nodule that is deemed highly suspicious for lung cancer based on: nodule characteristics, risk factors, CT-PET avidity, previous biopsy results, and assessment by physicians specializing in lung cancers
* Eligible for treatment
* Current cigarette smoking ≥5 cigarettes per day
* Willing to attempt smoking cessation during prehab period
* Willing to take nicotine replacement therapy (NRT) and varenicline
* Able to attend PR at UVMMC for 2, one-hour sequential sessions for a total of 16 sessions over 8 days during treatment
* Willing and able to provide informed consent; ability determined by study physician and/or LMDC treatment physicians

Exclusion Criteria:

* Unable to safely participate in PR due to unstable cardiac disease, unstable peripheral vascular disease, musculoskeletal disease that would prevent exercise, significant psychiatric or neurocognitive disease that would limit ability to exercise safely in a group setting as determined by the study physician and/or treatment physicians
* Inability to consistently attend PR during treatment
* Pregnancy, per patient self-report
* Active or recent participation in another clinical trial that, in the opinion of the investigator would impact outcomes measured in this study
* Any other condition in the opinion of the investigator/study physician and or treatment physicians that would jeopardize patient safety or integrity of research results

Where it's running

• University of Vermont Medical Center
  Burlington, Vermont, United States Recruiting

Study contacts

• Study coordinator: Olivia J Garrow, MS, RDN
• Email: olivia.johnson@uvmhealth.org
• Phone: 802-847-2160

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.