Preoperative HbA1c and risk of acute kidney injury after isolated coronary artery bypass
Official title: "The Association Between Preoperative HbA1c Levels and Postoperative Acute Kidney Injury in Isolated Coronary Artery Bypass Surgery: A Prospective Observational Study"
Run by Bursa Sevket Yilmaz Training and Research Hospital · NCT07445997 · Data updated 2026-11-12
This will see if higher pre-surgery HbA1c levels are linked to acute kidney injury in people having isolated elective coronary artery bypass surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Bursa Sevket Yilmaz Training and Research Hospital Government |
| Locations | 1 site (Bursa) |
| Status | Recruiting |
| Started | January 20, 2026 |
| Main results expected | August 30, 2026 |
| Study ends | August 30, 2026 |
| Registry record updated | March 3, 2026 |
| Trial ID | NCT07445997 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for isolated elective CABG with available preoperative HbA1c and Doppler renal resistive index measurements and without chronic kidney disease or advanced heart failure are ideal candidates.
✕Probably not a fit
Patients with preexisting chronic kidney disease, emergency or combined valve procedures, a single kidney or preoperative serum creatinine >2.0 mg/dL are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational cohort of patients undergoing isolated elective coronary artery bypass grafting at a single tertiary center in Bursa, Turkey. Participants must have available preoperative HbA1c and pre/postoperative Doppler renal resistive index measurements and patients with chronic kidney disease, emergency or redo surgeries, concomitant valve procedures, severe heart failure, or very elevated creatinine are excluded. The primary outcome is postoperative acute kidney injury, and analyses will examine whether higher preoperative HbA1c predicts AKI after adjusting for known clinical risk factors. Findings aim to clarify the relationship between long-term glycemic control and renal complications after CABG.
Why it matters
Potential benefit: If successful, the findings could help identify patients at higher risk of postoperative AKI so clinicians can optimize glucose control, monitoring, and preventive care before and after surgery.
How similar studies have gone: Prior observational studies have suggested an association between elevated preoperative HbA1c and higher AKI risk after cardiac surgery, but results have not been uniformly conclusive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing isolated elective CABG surgery * Patients with available preoperative and postoperative Doppler RRI measurements * Patients with available HbA1c data Exclusion Criteria: * Patients with chronic kidney disease * Emergency surgeries * Redo/revision surgeries * Patients undergoing concomitant valve surgery * Presence of acute infection or sepsis * Advanced heart failure (EF \<30%) * Requirement for intra-aortic balloon pump, pacemaker, or mechanical circulatory support * History of nephrectomy or single kidney * Preoperative serum creatinine \>2.0 mg/dL * Pregnancy * Refusal to participate in the study
Where it's running
-
University of Health Sciences, Bursa Yuksek Ihtisas Training & Research Hospital
Bursa, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Osman Sila Aydin
- Email: osmansila@gmail.com
- Phone: +(90)5059661014
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.