Preoperative HbA1c and risk of acute kidney injury after isolated coronary artery bypass
"The Association Between Preoperative HbA1c Levels and Postoperative Acute Kidney Injury in Isolated Coronary Artery Bypass Surgery: A Prospective Observational Study"
This will see if higher pre-surgery HbA1c levels are linked to acute kidney injury in people having isolated elective coronary artery bypass surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Bursa Sevket Yilmaz Training and Research Hospital Government |
| Locations | 1 site (Bursa) |
| Trial ID | NCT07445997 on ClinicalTrials.gov |
What this trial studies
This is an observational cohort of patients undergoing isolated elective coronary artery bypass grafting at a single tertiary center in Bursa, Turkey. Participants must have available preoperative HbA1c and pre/postoperative Doppler renal resistive index measurements and patients with chronic kidney disease, emergency or redo surgeries, concomitant valve procedures, severe heart failure, or very elevated creatinine are excluded. The primary outcome is postoperative acute kidney injury, and analyses will examine whether higher preoperative HbA1c predicts AKI after adjusting for known clinical risk factors. Findings aim to clarify the relationship between long-term glycemic control and renal complications after CABG.
Who should consider this trial
Good fit: Adults scheduled for isolated elective CABG with available preoperative HbA1c and Doppler renal resistive index measurements and without chronic kidney disease or advanced heart failure are ideal candidates.
Not a fit: Patients with preexisting chronic kidney disease, emergency or combined valve procedures, a single kidney or preoperative serum creatinine >2.0 mg/dL are excluded and unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the findings could help identify patients at higher risk of postoperative AKI so clinicians can optimize glucose control, monitoring, and preventive care before and after surgery.
How similar studies have performed: Prior observational studies have suggested an association between elevated preoperative HbA1c and higher AKI risk after cardiac surgery, but results have not been uniformly conclusive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing isolated elective CABG surgery * Patients with available preoperative and postoperative Doppler RRI measurements * Patients with available HbA1c data Exclusion Criteria: * Patients with chronic kidney disease * Emergency surgeries * Redo/revision surgeries * Patients undergoing concomitant valve surgery * Presence of acute infection or sepsis * Advanced heart failure (EF \<30%) * Requirement for intra-aortic balloon pump, pacemaker, or mechanical circulatory support * History of nephrectomy or single kidney * Preoperative serum creatinine \>2.0 mg/dL * Pregnancy * Refusal to participate in the study
Where this trial is running
Bursa
- University of Health Sciences, Bursa Yuksek Ihtisas Training & Research Hospital — Bursa, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Osman Sila Aydin
- Email: osmansila@gmail.com
- Phone: +(90)5059661014
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.