Preoperative dexamethasone palmitate to prevent nausea and vomiting after open surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Dexamethasone palmitate is a long-acting formulation that may provide prolonged anti-inflammatory and antiemetic effects compared with standard dexamethasone. In this interventional comparison, adults undergoing elective open spinal, chest, or abdominal surgery under general anesthesia receive preoperative dexamethasone palmitate or standard dexamethasone and are followed for postoperative nausea and vomiting and safety outcomes. The protocol excludes patients with recent systemic glucocorticoid use, severe cardiac/hepatic/renal or systemic rheumatic disease, uncontrolled diabetes, active infection, cognitive impairment or severe mental illness, and pregnant or breastfeeding individuals. Outcomes include incidence of PONV in the early postoperative period (including within 24 hours) and adverse events related to steroid exposure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 to 65 years;
* Providing written informed consent;
* Perform elective open surgery (Spinal surgery, open chest surgery, open abdominal surgery) undergoing general anesthesia.

Exclusion Criteria:

* Known to be allergic to dexamethasone;
* Any systemic glucocorticoids within 3 months before trial entry;
* History of severe heart disease, liver/kidney failure, or systemic rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, et al);
* Cognitive impairment or severe mental illness;
* Uncontrolled diabetes or infectious diseases;
* Pregnancy or breastfeeding.

Where it's running

• Fang Luo
  Beijing, China Recruiting

Study contacts

• Study coordinator: Fang Luo
• Email: 13611326978@163.com
• Phone: 59976661

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.