Preoperative dexamethasone palmitate to prevent nausea and vomiting after craniotomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Dexamethasone palmitate, a lipid-formulated longer-acting corticosteroid, is being compared with standard dexamethasone given before elective craniotomy. Adult patients aged 18–65 undergoing general anesthesia will receive one of the two preoperative treatments and be followed for postoperative nausea and vomiting and adverse events. The main outcome is PONV within the first 24 hours after surgery, with additional data on rescue antiemetic use and safety. Patients with recent systemic steroids, severe organ dysfunction, uncontrolled diabetes, pregnancy or steroid allergy are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 to 65 years;
* Providing written informed consent;
* Perform elective craniotomy undergoing general anesthesia.

Exclusion Criteria:

* Known to be allergic to dexamethasone;
* Any systemic glucocorticoids within 3 months before trial entry;
* History of severe heart disease, liver/kidney failure, or systemic rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, et al);
* Cognitive impairment or severe mental illness;
* Uncontrolled diabetes or infectious diseases;
* Pregnancy or breastfeeding.

Where it's running

• Fang Luo
  Beijing, China Recruiting

Study contacts

• Study coordinator: Fang Luo
• Email: 13611326978@163.com
• Phone: 59976661

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.