Preoperative blood inflammation markers to predict nausea after orchiopexy in children
Association of Preoperative Inflammatory Biomarkers With Postoperative Nausea and Vomiting in Children Undergoing Orchiopexy
This project will test whether preoperative blood inflammation markers can help predict which children aged 1–8 will have nausea and vomiting after orchiopexy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 170 (estimated) |
| Ages | 1 Year to 8 Years |
| Sex | All |
| Sponsor | Diskapi Yildirim Beyazit Education and Research Hospital Government |
| Locations | 1 site (Altındağ, Ankara) |
| Trial ID | NCT07148063 on ClinicalTrials.gov |
What this trial studies
This prospective observational study will enroll children aged 1–8 undergoing elective orchiopexy and record preoperative inflammatory markers including NLR, PLR, SII, MLR, and SIRI. Blood counts will be measured before surgery and patients will be monitored for postoperative nausea and vomiting during the immediate recovery period. Researchers will analyze whether baseline marker levels correlate with PONV incidence while excluding children with active infection, prior nausea/vomiting history, or ASA III+ status. The goal is to see if routine laboratory measures can identify higher-risk children for targeted prophylaxis.
Who should consider this trial
Good fit: Ideal candidates are children aged 1–8 years with ASA physical status I–II who are scheduled for elective orchiopexy and whose parents/guardians can give informed consent.
Not a fit: Children outside the 1–8 year range, those with active infections, ASA III or higher, or a history of prior nausea/vomiting are excluded and unlikely to benefit from these findings.
Why it matters
Potential benefit: If successful, clinicians could use routine preoperative blood counts to identify children at higher risk of PONV and offer targeted anti-nausea prevention.
How similar studies have performed: Previous adult and some pediatric studies have linked inflammatory markers like NLR and PLR to postoperative complications and PONV risk, but applying SII, MLR, and SIRI specifically to young orchiopexy patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged between 1 and 8 years * Patients with ASA physical status I-II * Patients scheduled for elective orchiopexy * Obtained written informed consent from parents/guardians Exclusion Criteria: * Patients younger than 1 year or older than 8 years * Patients with ASA physical status III or higher * Presence of acute infection signs * History of previous nausea or vomiting
Where this trial is running
Altındağ, Ankara
- Ankara Etlik City Hospital — Altındağ, Ankara, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Elif Şule Özdemir Sezgi
- Email: elifsule-91@hotmail.com
- Phone: 00905059209638
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.