Prenatal diagnosis and management of congenital talipes equinovarus
Congenital Talipes Equinovarus Prenatal Diagnosis and Closed Loop Management System Single Center Observational Prospective Study Clinical Study Protocol
This study is trying to improve how we diagnose and treat clubfoot in babies, starting from pregnancy and continuing after birth, by using advanced imaging and genetic testing.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Trial ID | NCT05638490 on ClinicalTrials.gov |
What this trial studies
This study aims to create a comprehensive management system for congenital talipes equinovarus, starting from prenatal diagnosis and extending to postnatal care. It will utilize advanced imaging techniques such as ultrasound and MRI to establish a diagnostic evaluation system. Additionally, the study will employ whole-exome sequencing to identify potential genetic causes of the condition, enhancing understanding of its pathogenic mechanisms. The goal is to improve diagnostic and treatment capabilities, ultimately reducing disability rates associated with this condition.
Who should consider this trial
Good fit: Ideal candidates for this study are single pregnant women whose ultrasound suggests congenital talipes equinovarus.
Not a fit: Patients with twin or multiple pregnancies will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly enhance the diagnosis and management of congenital talipes equinovarus, leading to better outcomes for affected infants.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in improving prenatal diagnosis and management of congenital conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1）Single pregnant women 2) "congenital talipes equinovarus" suggested by ultrasound Exclusion Criteria: Twin or multiple pregnancies
Where this trial is running
Nanjing, Jiangsu
- Drum Tower hospital — Nanjing, Jiangsu, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.