Prehabilitation with resistance exercise and nutritional support before allogeneic stem cell transplant
Prehabilitation for Patients Diagnosed With Blood Cancer and Treated With Alloge-neic Hematopoietic Stem Cell Transplantation - a National Randomized Controlled Trial
This trial tests whether a personalized program of resistance exercise plus nutritional support given before an allogeneic stem cell transplant helps adult patients stay stronger and feel better after transplant.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Rigshospitalet, Denmark Academic / other |
| Locations | 1 site (Copenhagen, Denmark) |
| Trial ID | NCT07341698 on ClinicalTrials.gov |
What this trial studies
This randomized interventional trial compares an individualized prehabilitation program (resistance training plus nutritional support) added to usual care versus usual care alone for adults awaiting allogeneic hematopoietic stem cell transplantation. The intervention begins at least four weeks before the scheduled transplant and is tailored to each patient's needs and abilities. The primary outcome is health-related quality of life, with secondary outcomes including hospitalization metrics, muscle mass, and muscle function. Patients must be able to perform muscle testing and read Danish or English to participate.
Who should consider this trial
Good fit: Adults aged 18 or older who are scheduled for an allogeneic hematopoietic stem cell transplant with at least four weeks before the procedure and who can complete muscle function testing and understand Danish or English are ideal candidates.
Not a fit: Patients who are pregnant, who have physical or cognitive impairments preventing muscle testing or exercise, or who cannot read Danish or English are excluded and unlikely to benefit from this program.
Why it matters
Potential benefit: If successful, the approach could help patients preserve muscle mass and strength, reduce hospital-related complications, and improve quality of life around the time of transplant.
How similar studies have performed: Smaller feasibility and safety studies of exercise-based prehabilitation before transplant have shown it is safe and feasible, but large randomized trials demonstrating clinical benefit are still lacking.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adult patients \>18 years will be eligible for inclusion if they are scheduled for a allo-HSCT with at least four weeks before their scheduled transplantation date. Exclusion Criteria: * pregnancy * physical or mental disabilities precluding test of muscle function * inability to read and understand Danish or English
Where this trial is running
Copenhagen, Denmark
- Copenhagen University Hospital - Rigshospitalet — Copenhagen, Denmark, Denmark (Recruiting)
Study contacts
- Study coordinator: Jan Christensen, PhD
- Email: jan.christensen.02@regionh.dk
- Phone: +4522479075
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.