Prehabilitation using adapted physical activity for multiple myeloma patients before autologous stem cell transplant
Evaluation of a PREHABilitation Protocol Using Adapted Physical Activity (APA) for Multiple Myeloma Patients Eligible for Intensive Autologous Stem Cell Transplantation Treatment (PREHAB-APA)
This tests whether a prehabilitation program of adapted physical activity can help adults with multiple myeloma preparing for autologous stem cell transplant reduce fatigue and improve quality of life.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Henri Duffaut - Avignon Academic / other |
| Locations | 1 site (Avignon) |
| Trial ID | NCT06789003 on ClinicalTrials.gov |
What this trial studies
This interventional, single-center program compares a structured adapted physical activity (APA) prehabilitation program to usual care (no intervention) for patients with multiple myeloma who are eligible for autologous stem cell transplantation. Outcomes include validated questionnaires on quality of life, fatigue, and physical activity, and feasibility measures focused on adherence (completed vs planned sessions) and attrition. The protocol excludes patients with medical contraindications to exercise, significant neuropathy, recent other cancers, or legal/psychosocial barriers to participation. The program is delivered at Centre Hospitalier Henri Duffaut in Avignon and requires a medical prescription for APA.
Who should consider this trial
Good fit: Adults (≥18) with a diagnosis of multiple myeloma who are eligible for autologous stem cell transplantation, able to read French, have WHO performance status ≤2, hold French social security, and have a medical prescription for adapted physical activity are ideal candidates.
Not a fit: Patients with medical contraindications to exercise (for example unstable cardiac disease, severe osteoporosis or bone metastases), sensory or motor neuropathy, recent other cancers, or those unable/unwilling to adhere to the program are unlikely to benefit.
Why it matters
Potential benefit: If successful, the program could reduce fatigue and improve physical condition and quality of life before transplant, potentially improving readiness for autologous stem cell transplantation.
How similar studies have performed: Previous adapted physical activity programs in hematologic malignancies have often shown improvements in quality of life and fatigue but results are mixed and frequently limited by low adherence, so the approach is partially supported but not definitively proven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years old. * CML patient in chronic phase, eligible for oral therapy. * Diagnosis of multiple myeloma. * Patient eligible for autologous stem cell transplantation. * Patient capable to read, understand and complete a questionnaire in french. * WHO less than or equal to 2. * Patient affiliated with french social security. * Patient with a medical prescription for APA. Exclusion Criteria: * Patient with previous cancer within the previous 3 years (except basal cell and squamous cell skin cancers, carcinomas in situ of any type that have been previously resected, and stable prostate or breast cancers more than 3 years old and undergoing adjuvant hormone therapy). * Medical contraindications to APA (heart failure, angina, unbalanced hypertension, bone metastases, severe osteoporosis, etc.) * Sensory or motor neuropathy. * Patient deprived of liberty, under guardianship or curatorship. * Patient considered socially or psychologically unfit to be enrolled in a study.
Where this trial is running
Avignon
- Centre Hospitalier d'Avignon, Hôpital Henri Duffaut — Avignon, France (Recruiting)
Study contacts
- Study coordinator: Marilyne Grinand, PhD
- Email: grinand.marilyne@ch-avignon.fr
- Phone: (+33)432759392
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.