Prehabilitation program for lung cancer surgery patients
A Novel Multimodal Intervention for Surgical Prehabilitation of Patients With Lung Cancer: the MMP-LUNG Trial
This study is testing if a special program that combines exercise and a nutrient supplement can help lung cancer patients feel stronger and recover better after surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 168 (estimated) |
| Ages | 45 Years and up |
| Sex | All |
| Sponsor | McGill University Academic / other |
| Locations | 1 site (Montreal, Quebec) |
| Trial ID | NCT05955248 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial investigates the effects of a multimodal prehabilitation intervention that combines a mixed-nutrient supplement with structured exercise training, compared to the supplement alone and a placebo. The study aims to improve functional capacity and postoperative outcomes in lung cancer patients at nutritional risk. Participants aged 45 and older will undergo a 10-week intervention, including assessments of muscle mass, quality of life, and postoperative complications. The primary outcome will be measured using the 6-minute walk test.
Who should consider this trial
Good fit: Ideal candidates are adults aged 45 and older diagnosed with non-small cell lung cancer and scheduled for surgery, who are also at nutritional risk.
Not a fit: Patients with recent adjuvant therapy, severe comorbidities, or those unable to perform exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could enhance recovery and overall outcomes for lung cancer surgery patients.
How similar studies have performed: Other studies have shown promising results with multimodal prehabilitation approaches, suggesting potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 45 years and over * Diagnosed with NSCLC stages I, II or IIIa and scheduled for video-assisted thoracic surgery (VATS) or open thoracotomy surgery for cancer resection * At nutritional risk (defined as Patient Generated-Subjective Global Assessment score = or \>3) Exclusion Criteria: * Prior recent (\<2 months) adjuvant therapy (chemo- or radio-therapy) * Inability to perform, or comorbidities contraindicating, exercise (defined as CPET \<10 mL O2/kg/min) * Unable to walk (uses a wheelchair) * Allergy to milk or seafood * Hypercalcemia (total serum Ca \>2.60 mmol/L or ionized Ca \>1.30 mmol/L) * Hypervitaminosis D (serum 25(OH)D \>375 nmol/L) * Glomerular filtration rate (\<30 mL/min/1.73m2) * Insufficient understanding of English or French to provide informed consent Patients taking omega-3 FA supplements will be asked to withhold them during the study; those taking vitamin D will continue unless baseline serum 25(OH)D \>80 nmol/L.
Where this trial is running
Montreal, Quebec
- Research Institute of the McGill University Health Centre — Montreal, Quebec, Canada (Recruiting)
Study contacts
- Principal investigator: Stéphanie Chevalier, PhD — McGill University
- Study coordinator: Stéphanie Chevalier, PhD
- Email: stephanie.chevalier@mcgill.ca
- Phone: (514) 934-1934
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.