Prehabilitation program for kidney transplant candidates
PREhabilitation of CAndidates for REnal Transplantation: a Hybrid Study
This study is testing a special health program for people waiting for a kidney transplant to see if it helps them become stronger and healthier before their surgery compared to those who get regular care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 128 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Medical Center Groningen Academic / other |
| Locations | 1 site (Groningen) |
| Trial ID | NCT05489432 on ClinicalTrials.gov |
What this trial studies
This study offers a personalized, multi-modal prehabilitation intervention to 64 patients on the kidney transplant waiting list, comparing their outcomes to a control group receiving standard care. Eligible candidates will be screened for physical, nutritional, and psychological issues and randomly assigned to either the intervention or control group. The intervention consists of a 12-week prehabilitation program followed by a 12-week consolidation phase, with the primary outcome being frailty status measured at three time points. The goal is to enhance the overall health status of kidney transplant candidates to better prepare them for surgery and recovery.
Who should consider this trial
Good fit: Ideal candidates are adult patients (18 years and older) who are on the kidney transplant waiting list at the University Medical Center Groningen.
Not a fit: Patients who are unable to read or speak Dutch, those requiring combined organ transplants, or those involved in other lifestyle intervention programs may not benefit from this study.
Why it matters
Potential benefit: If successful, this program could significantly improve the health and recovery outcomes for kidney transplant candidates.
How similar studies have performed: While research on prehabilitation in transplant populations is limited, existing studies suggest that such interventions are safe, feasible, and may positively impact pre- and postoperative outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adult kidney transplant candidates (≥18 years) 2. Listed for kidney transplantation on the UMCG kidney transplant waiting list at the start of the study or wait listed during the inclusion period (October 2022 - March 2025). Exclusion Criteria: 1. Inability to read and/or speak Dutch 2. Combined organ transplantation (e.g., kidney+pancreas, kidney+liver) 3. In case of living donor kidney transplant: a transplantation planned within 3 months 4. Involved in a lifestyle intervention program
Where this trial is running
Groningen
- University Medical Center Groningen — Groningen, Netherlands (Recruiting)
Study contacts
- Principal investigator: Coby Annema, PhD — University Medical Center Groningen
- Study coordinator: Coby C Annema, PhD
- Email: j.h.annema@umcg.nl
- Phone: +31621551352
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.