Predicting swallowing difficulties after partial laryngectomy using subglottic pressure measurements
Department of Otolaryngology Head Neck Surg
This study is testing if measuring pressure in the throat can help predict how well people recovering from partial laryngectomy for laryngeal cancer will be able to swallow.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Guangdong Provincial People's Hospital Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06024980 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the relationship between subglottic pressure and swallowing function recovery in patients undergoing partial laryngectomy for laryngeal cancer. Participants are divided into two groups based on the stage of their cancer and receive either transoral endoscopic laser cordectomy or open partial horizontal laryngectomy. Swallowing function is assessed through various methods, including subglottic pressure measurements and questionnaires, at multiple time points post-surgery. The goal is to identify predictors of dysphagia recovery and improve patient outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-80 undergoing surgical treatment for squamous cell carcinoma with normal swallowing of thin liquids.
Not a fit: Patients with severe chronic obstructive pulmonary disease, severe heart disease, or pre-existing swallowing disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prediction and management of swallowing difficulties in patients after laryngectomy.
How similar studies have performed: While some studies have explored predictors of swallowing function recovery, the specific focus on subglottic pressure in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18-80 years * Surgical treatment by open partial horizontal laryngectomy type I or II and transoral laser cordectomy for squamous cell carcinoma * Availability of clinical data * Validity of normal swallowing of thin liquids Exclusion Criteria: * Presence of severe chronic obstructive pulmonary disease, severe heart disease, and psychopathy or mental disease * Surgery complications(such as sepsis, pharyngocutaneous fistula, surgical revision) * Radiotherapy histology * Swallowing disorder or trachea aspiration before surgery.
Where this trial is running
Guangzhou, Guangdong
- Guangdong Provincial People's hospital — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Principal investigator: Xujiao Chen, Ms — Guangdong Provicial People's Hospital（Guangdong Academy of Sciences), Southern Medical University
- Study coordinator: Pingjiang Ge, M.D.
- Email: gepingjiang@aliyun.com
- Phone: +8613751753465
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.