Predicting survival in people with manifest tetanus using three severity scores.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this observational cohort at Ain Shams University Hospitals and Demanhour Fever Hospital, adults admitted to the ICU with manifest tetanus will have three severity scores recorded on admission: the Tetanus Severity Score (TSS), Dakar Score, and Philips Score. Researchers will compare each score to the primary outcome of in-hospital mortality versus survival to hospital discharge. Patients younger than 18, those who do not meet WHO criteria for manifest tetanus, or cases with incomplete records for scores or outcomes will be excluded. The analysis will describe how well each score predicts mortality and may identify score thresholds linked to higher risk.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Adults (age 18 years old or more).
* Any sex (male or female), regardless of gender identity.
* Diagnosis of manifest tetanus according to the WHO criteria (https://www.who.int/news-room/fact-sheets/detail/tetanus), that is the presence of one or both of the following criteria with or without the history of specific wound or injury:

  * Sustained spasm of the facial muscles in which person appears grinning.
  * Painful muscular contractions

Exclusion criteria:

* Age \< 18 years.
* Absent criteria of manifest tetanus, as per the WHO criteria (https://www.who.int/news-room/fact-sheets/detail/tetanus).
* Incomplete medical record with missing data required to calculate the Tetanus Severity Score, Philips Score, or Dakar score.
* Incomplete medical record with missing data regarding the primary outcome measure (survival to hospital discharge or in-hospital mortality).

Where it's running

• Ain Shams University Hospitals & Demanhour Fever Hospital
  Cairo, Cairo Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Sameh M Hakim, MD
• Email: hakimsm@med.asu.edu.eg
• Phone: +202 26900073

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.