Predicting sperm retrieval success in men with non-obstructive azoospermia
The Value of Composite Measurements of Extracellular Matrix Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive Azoospermia
This study is trying to find out if certain markers in men with non-obstructive azoospermia can help predict how successful sperm retrieval will be, to improve treatment options for couples dealing with infertility.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 18 Years and up |
| Sex | Male |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06154954 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify molecular and biochemical markers that can predict the success of sperm retrieval in men diagnosed with non-obstructive azoospermia. By analyzing testicular proteins and other indicators, the study seeks to improve the understanding of spermatogenesis and enhance the chances of successful sperm extraction. The research will involve semen analysis and may provide insights into the histological characteristics of the testis. The ultimate goal is to better inform treatment options for couples facing infertility due to this condition.
Who should consider this trial
Good fit: Ideal candidates for this study are men diagnosed with non-obstructive azoospermia.
Not a fit: Patients with obstructive azoospermia or those with specific genetic conditions such as sex reversal syndrome or Y chromosome microdeletions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly improve the chances of sperm retrieval for men with non-obstructive azoospermia, leading to better fertility outcomes.
How similar studies have performed: While there have been studies exploring similar predictive markers, the specific approach of this study focusing on testicular proteins in non-obstructive azoospermia is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men with Non-obstructive azoospermia Exclusion Criteria: 1. Sex reversal syndrome. 2. Macro-deletion on the Y chromosome (To those accepting the chromosomal study) 3. AZF a, AZF b microdeletion (To those accepting the Y chromosome microdeletion analysis). 4. Obstructive azoospermia. 5. Undescended testis. 6. Hypogonadotrophic Hypogonadism 7. Testicular procedures and operations -
Where this trial is running
Cairo
- Cairo University hospital, department of andrology — Cairo, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.