Predicting recurrence of high-risk colorectal polyps using microbiota and metabolites

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study analyzes the characteristics of intestinal microbiota in patients who have undergone polypectomy for high-risk colorectal polyps. It aims to understand the relationship between microbial communities and the recurrence of these polyps, which could provide insights into the etiology of adenoma recurrence. By developing a prediction model based on microbiota and metabolites, the research seeks to enhance patient management and outcomes following polypectomy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients aged 40-75 years who undergo the colonoscopy with at least 1 advanced premalignant polyps or ≥ 3 adenoma

Exclusion Criteria:

* patient with severe physical diseases that prevented them from adhering to the examination requirements,
* patient with coagulopathy or other contraindications for biopsy or polypectomy,
* patient with previous surgical procedures on the gastrointestinal tract,
* presence of colorectal cancer or other malignant tumor at baseline
* presence of inflammatory bowel disease or hereditary polyposis syndromes (such as family adenomatous polyposis or Lynch syndrome)
* within 1 month before enrollment, oral antibiotics and probiotics were taken;
* inability to provide informed consent or refusal to participate in the study.

Where it's running

• Peking Union Medical College Hospital, 1 Shuaifuyuan, Dongcheng District, Beijing, China
  Beijing, China Recruiting

Study contacts

• Study coordinator: Cheng Peng, MD
• Email: pengchengf@mail.sdu.edu.cn
• Phone: +86 18500743525

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.