Predicting recovery after acute ischemic stroke using neurologists' judgments and AI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational project enrolls patients with suspected acute ischemic stroke presenting to a tertiary stroke unit and collects the clinical and imaging information used by treating neurologists. Treating neurologists will make real-time outcome predictions (NIHSS at 24 hours and 3 months, and mRS at 3 months), and deep-learning models will be given the same structured clinical and imaging inputs to generate predictions. The team will compare predictive performance, identify which baseline variables drive decisions for both humans and models, and perform error analyses on misclassifications. Findings will be used to refine the algorithm and improve handling of multimodal clinical and imaging data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients from up to 18 years years of age without any upper age limit.
* Patients with clinical suspicion of acute ischemic stroke (acute onset focal neurological deficit) at the discretion of the paramedic or treating physician within 24 hours of symptom onset including wake-up situation and unclear symptom onset planned for clinically indicated neuroimaging.
* Patients with externally performed neuroimaging before admission or referral to the USZ will be included from the time point N2 on if no refusal of use of data is documented.

Exclusion Criteria:

• Patients with documented objection of subsequent use of personal health data or patients who reject the use of personal health data during follow-up after initial informed consent by an independent physician in the acute setting. We will not include patients in the study if there is no written informed consent either from the patient her-/himself, the next of kin or the independent physician.

Where it's running

• University Hospital Zurich, Department of Neurology
  Zurich, Switzerland Recruiting

Study contacts

• Study coordinator: Laura Philine Westphal, MD
• Email: lauraphiline.westphal@usz.ch
• Phone: 0041432537590

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.