Predicting rebleeding risk in patients with acute gastrointestinal bleeding

Construction of a Clinical Prediction Model for In-Hospital Rebleeding in Patients With Acute Non-Venous Upper Gastrointestinal Bleeding

This study is trying to create a better way to predict which patients who have had serious stomach bleeding are at risk of bleeding again, so doctors can provide better care and prevention.

Quick facts

• Study type: Observational
• Enrollment: 1000 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Wuhan Central Hospital (Academic / other)
• Locations: 1 site (Wuhan, Hubei)
• Trial ID: NCT06697691 on ClinicalTrials.gov

What this trial studies

This study aims to develop a new clinical prediction model for identifying patients at high risk of rebleeding after experiencing acute non-variceal upper gastrointestinal bleeding. Current prediction tools are not sufficiently effective, prompting the need for a more accurate model that incorporates patient symptoms, lab results, and imaging findings. By improving risk assessment, the study seeks to enhance clinical decision-making regarding preventive treatments and monitoring strategies for these patients.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old diagnosed with acute non-variceal upper gastrointestinal bleeding who have undergone endoscopy within 24 hours of admission.

Not a fit: Patients with upper gastrointestinal bleeding during hospitalization, variceal bleeding, or those with incomplete clinical data will not benefit from this study.

Why it matters

Potential benefit: If successful, this model could significantly reduce the incidence of rebleeding and improve patient outcomes.

How similar studies have performed: While existing prediction tools have been used, this approach aims to create a novel model, indicating it is an untested methodology.

Eligibility criteria

Inclusion Criteria:

* age exceeding 18 years,
* Clinical diagnosis of Acute Non-Variceal Upper Gastrointestinal Bleeding ,
* patients who underwent endoscopy within 24 hours of admission with confirmation of non-variceal bleeding

Exclusion Criteria:

* Upper Gastrointestinal Bleeding during hospitalization;
* transfer from other hospitals;
* variceal bleeding;
* lower gastrointestinal bleeding.;
* bleeding attributed to systemic diseases like disseminated intravascular coagulation (DIC) and hematological disorders;
* patients with incomplete clinical data or laboratory test results;
* patients who either requested early discharge or declined gastroscopy.

Where this trial is running

Wuhan, Hubei

• the Central Hospital of Wuhan — Wuhan, Hubei, China (Recruiting)

Study contacts

• Study coordinator: junwei yan

Conditions Acute Non-variceal Upper Gastrointestinal Bleeding; rebleeding; acute non-variceal upper gastrointestinal bleeding