Predicting progression of myeloma in high-risk individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to collect data and biospecimens from participants to investigate the early detection of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) in a high-risk population. By characterizing genomic, epigenomic, and immune factors associated with disease progression, the research seeks to develop strategies that can intercept the progression of these conditions. The study will involve blood sampling and will focus on individuals with a family history of plasma cell dyscrasias. The overarching goal is to improve survival rates by initiating treatment before the onset of symptomatic disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Must meet criteria of the high-risk population as described with one of the below criteria

  * ≥ 30 years AND
  * first-degree relative of a patient with a plasma cell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia, or another blood cancer.

OR

* Age ≥ 18 years with 2 or more first- or second-degree relatives with a plasma cell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia, or another blood cancer '
* Voluntary written informed consent must be given with the understanding that consent may be withdrawn by the patient at any time without prejudice to future medical care

Exclusion Criteria:

* • Persons diagnosed with cancer at any site (including hematologic cancers) with symptomatic disease requiring active therapy.

  * Persons with an already diagnosed plasma cell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia
  * Female patient who have a positive serum pregnancy test during the screening period or a positive pregnancy test.

Where it's running

• Soroka
  Beersheba, Israel Recruiting
• Rambam healthcare campus
  Haifa, Israel Recruiting
• Rabin medical center
  Petah Tikva, Israel Recruiting
• Tasmc
  Tel Aviv, Israel Recruiting

Study contacts

• Study coordinator: Irit Avivi, Prof
• Email: iritavi@tlvmc.gov.il
• Phone: -97236973782

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.