Clinical trial Recruiting at 1 site Observational Ages 20 to 50 Women only

Predicting pregnancy risks for women with aplastic anemia

Official title: Development and Validation of a Prediction Model for Adverse Pregnancy Outcomes in Women With Aplastic Anemia

Run by Peking University People's Hospital · NCT07101770 · Data updated 2026-11-12

This project will try to create a model to predict which pregnant women with aplastic anemia are most likely to have maternal or newborn complications.

Quick facts

Study typeObservational
Ages20 Years to 50 Years
SexWomen only
Enrollment300 (estimated)
SponsorPeking University People's Hospital
Academic / other
Locations1 site (Beijing)
StatusRecruiting
StartedNovember 27, 2025
Main results expectedJune 30, 2030
Study endsDecember 31, 2030
Registry record updatedDecember 1, 2025
Trial IDNCT07101770 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Pregnant women aged 20 or older who have aplastic anemia either before pregnancy or newly diagnosed during pregnancy, carrying a single fetus and with available coagulation testing, are the intended participants.

Probably not a fit

Women younger than 20, those with multiple pregnancies, pregnancies terminated before 20 weeks, or lacking key coagulation data are excluded and may not receive benefit from the model.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter study combines retrospective chart review with a prospective cohort to collect clinical, laboratory, treatment, and outcome data from pregnant women with aplastic anemia. Participants will be followed through questionnaires, phone or video visits, online platforms, and in-person visits to capture maternal and perinatal outcomes. Collected variables will include baseline demographics, coagulation and hematologic results, comorbidities, and treatments to develop a risk prediction model. The goal is to use pooled data from several Chinese hospitals to produce a validated tool for dynamic risk stratification in this rare high-risk group.

Why it matters

Potential benefit: If successful, the model could help clinicians identify high-risk pregnancies early so care can be intensified or tailored to reduce complications for mother and baby.

How similar studies have gone: Most prior reports are small, single-center retrospective series and there are currently no widely validated predictive tools for aplastic anemia in pregnancy, so this multicenter prospective approach is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. pregnant women who had aplastic anemia before pregnancy
2. pregnant women with newly diagnosed aplastic anemia during pregnancy

Exclusion Criteria:

1. age less than 20 years
2. without coagulation series results
3. termination of pregnancy before 20 weeks of gestation
4. multiple pregnancy

Where it's running

  • Peking University People's Hospital
    Beijing, China
    Recruiting

Study contacts

  • Principal investigator: Xiaohui Zhang, MD — Peking University People's Hospital
  • Study coordinator: Xiaohui Zhang, MD
  • Email: zhangxh@bjmu.edu.cn
  • Phone: +8613522338836

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.