Predicting opioid misuse and pain after spine surgery
Neurocognitive and Genomic Predictors of Persistent Pain and Opioid Misuse After Spine Surgery
Icahn School of Medicine at Mount Sinai · NCT06288256
This study looks at whether certain behaviors and genetic markers can help predict which patients having spine surgery might struggle with opioid misuse and ongoing pain afterwards.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Icahn School of Medicine at Mount Sinai (other) |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT06288256 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how neurocognitive behaviors and genomic markers can predict the risk of opioid misuse and persistent pain in patients undergoing elective spine surgery. It focuses on assessing impulsivity, cognitive control, and genetic factors through patient surveys, cognitive tests, and blood samples. By understanding these predictors, the study aims to identify individuals at higher risk for developing opioid dependence and long-term pain issues following surgery.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 scheduled for elective spine surgery with diagnoses of lumbar, cervical, or thoracic spine pathology.
Not a fit: Patients with severe psychiatric conditions or significant comorbidities that interfere with study participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify patients at risk for opioid misuse, leading to targeted interventions that improve pain management and reduce dependency.
How similar studies have performed: While there is ongoing research in this area, this specific approach combining neurocognitive and genomic predictors is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18 * With diagnoses of lumbar, cervical or thoracic spine pathology, scheduled to undergo elective spine surgery with or without instrumentation Exclusion Criteria: * Severe psychiatric condition interfering with study participation Any major cardiac, pulmonary, renal, infectious, hepatic condition that interferes with study participation * Polytrauma * Prolonged hospitalization (\>10days) * Pregnancy * Known surgery cancellation within study period
Where this trial is running
New York, New York
- Mount Sinai Spine Center — New York, New York, United States (RECRUITING)
Study contacts
- Principal investigator: Chinwe Nwaneshiudu — Icahn School of Medicine at Mount Sinai
- Study coordinator: Chinwe Nwaneshiudu, MD PhD
- Email: chinwe.nwaneshiudu@mountsinai.org
- Phone: 212-241-4203
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Lumbar Spine Pathology, Elective Spine Surgery