Predicting heart muscle scarring in patients with mitral valve prolapse

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational study aims to develop a scoring model to predict myocardial fibrosis in patients diagnosed with mitral valve prolapse (MVP) using cardiac magnetic resonance imaging. It will analyze both prospective and retrospective data to identify specific features that may increase the risk of ventricular arrhythmias or sudden cardiac death in these patients. The study seeks to clarify which patients with MVP should undergo cardiac magnetic resonance to detect potential myocardial fibrosis, which is currently uncertain in routine clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age ≥ 18 years
* Echocardiographic diagnosis of mitral valve prolaspe, defined as a systolic displacement of one or both mitral leaflets ≥ 2 mm above the plane of the mitral valve annulus in long-axis views

Exclusion Criteria:

* age\< 18 years
* coexistence of other cardiomyopathies or other ≥ moderate valve diseases
* scarce acoustic transthoracic echocardiographic window
* usual contraindications for cardiac magnetic resonance

Where it's running

• Centro Cardiologico Monzino
  Milan, Milan, Italy Recruiting

Study contacts

• Study coordinator: Gianluca Pontone, MD
• Email: gianluca.pontone@cardiologicomonzino.it
• Phone: 0258002574

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting high-risk arrhythmic events in people with arrhythmic mitral valve prolapse

  This study tests a risk model to see which patients with arrhythmic mitral valve prolapse might need an ICD.

  Recruiting Oslo University Hospital · Oslo · NCT07830888

• AI and 3D ultrasound mapping of mitral valve prolapse shape and function.

  This project tests an automated AI system that uses intraoperative 3D transesophageal ultrasound to map mitral valve anatomy and create patient-specific biomechanical models for adults having surgery for degenerative mitral valve prolapse.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese · NCT07384871

• Korea VHD Echo Study: Real-World Practice of Aortic, Mitral, and Tricuspid Valves

  This study looks at how valvular heart disease is managed in Korea by reviewing echocardiograms and medical records from multiple centers to see patterns in disease progression and treatment.

  Recruiting at 2 sites Yonsei University · Seoul, Seoul and 1 other locations · NCT07068633

• Patient-centered decision-making for mitral valve prolapse treatment

  This study is trying to understand what patients with mitral valve prolapse and their doctors think about choosing between two treatment options, surgery or a less invasive procedure, to help improve how they make decisions together.

  Recruiting at 5 sites Northwell Health · Los Angeles, California and 4 other locations · NCT06738537

• Impact of mitral valve surgery on ventricular arrhythmias

  This study is testing how mitral valve surgery helps people with mitral valve prolapse and arrhythmias by looking at their heart health before and after the operation.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT06255457

• Observational registry for patients treated with the NeoChord Artificial Chordae System

  This study is looking at how well the NeoChord Artificial Chordae System works for people with degenerative mitral valve disease over five years, without needing any extra procedures beyond regular treatment.

  Recruiting at 5 sites NeoChord · Bonn and 4 other locations · NCT04190602

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.