Predicting BK Virus Reactivation in Kidney Transplant Recipients
Prediction of BK Virus Infection by Flow Cytometric Analysis of BK Virus-specific T Cell Responses in Kidney Transplant Recipients
This study is testing a new way to predict if kidney transplant patients will have a reactivation of the BK virus by looking at their blood for specific immune responses.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | King Chulalongkorn Memorial Hospital Academic / other |
| Locations | 1 site (Bangkok) |
| Trial ID | NCT06219616 on ClinicalTrials.gov |
What this trial studies
This study aims to develop a predictive tool for BK virus reactivation in kidney transplant recipients by utilizing flow cytometric analysis to assess intracellular cytokines and surface activation markers related to BKV-specific T cell responses. The research focuses on new kidney transplant cases and involves blood sampling to monitor immune responses post-transplantation. By identifying patients at risk for BKV reactivation, the study seeks to improve patient management and outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are undergoing new kidney transplantation.
Not a fit: Patients who are pregnant or have primary non-function of the kidney allograft will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better monitoring and prevention strategies for BK virus reactivation in kidney transplant patients.
How similar studies have performed: While there has been limited research on predicting BK virus reactivation, this approach using immune monitoring is novel and has not been extensively tested in this context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: 1. New kidney transplantation cases (either living donor or deceased donor transplantation) 2. Age ≥ 18 years old 3. Agree to give a permission to blood sampling post-transplantation, and at the time of BK viremia. Exclusion criteria: 1. Pregnant 2. Primary non-function of kidney allograft (i.e. kidney allograft never function).
Where this trial is running
Bangkok
- King Chulalongkorn Memorial Hospital — Bangkok, Thailand (Recruiting)
Study contacts
- Study coordinator: Suwasin Udomkarnjananun
- Email: suwasin.u@gmail.com
- Phone: 6622564000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.