PrecisionAge Pilot: a personalized multimodal healthy-aging program
PrecisionAge Pilot Study
NA · University of Zurich · NCT07523061
This pilot will test whether a combined program of physical activity, mindfulness, sleep routines, a calorie-restricted Mediterranean diet, and specific supplements can help slow signs of aging in adults 55–70 at risk for accelerated aging.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 55 Years to 70 Years |
| Sex | All |
| Sponsor | University of Zurich (other) |
| Locations | 1 site (Basel, Canton of Basel-City) |
| Trial ID | NCT07523061 on ClinicalTrials.gov |
What this trial studies
This pilot tests the feasibility of a multimodal lifestyle intervention for older adults at risk of accelerated functional and biological aging. Participants will follow a program including increased physical activity, mindfulness training, improved sleep routines, a calorie-restricted Mediterranean diet, and supplements (vitamin D, omega‑3, a multivitamin-mineral, and the plant-based Fruitflow®), with activity tracked by a wearable synced to a smartphone. The pilot is designed to prepare for a larger clinical trial by monitoring adherence, safety, and changes in functional and biomarker measures. The study is conducted at Universitäre Altersmedizin Felix Platter in Basel and requires German-language ability and smartphone use.
Who should consider this trial
Good fit: Community-dwelling adults aged 55–70 with low daily activity (<4000 steps/day), low fruit and vegetable intake (<3/day), overweight BMI (25.0–29.9), and at least one borderline lab value or blood pressure reading who can read/write German and use a smartphone are ideal candidates.
Not a fit: People outside the 55–70 age range, those already meeting activity and diet targets, individuals with BMI outside 25–29.9 or with advanced chronic disease, non-German speakers, or those unable to use a smartphone or tolerate a Mediterranean diet may not receive benefit from this pilot.
Why it matters
Potential benefit: If successful, the program could slow functional decline and improve biological risk markers such as blood pressure, lipids, inflammation, and glycemic measures.
How similar studies have performed: Previous multimodal lifestyle interventions combining diet and exercise have shown improvements in risk factors and function in older adults, although the specific supplement combination used here is less well studied in aging-focused pilots.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Community-dwelling women and men (sex) aged between 55 and 70 years * low daily exercise (i.e. \<4000 steps/day on average in the last month, self-assessment) * low fruit and vegetable intake (\< 3 per day) * at risk for accelerated functional and biological aging based on the following criteria: * overweight (BMI between 25.0 and 29.9) * at least one of the following lab values or at least borderline blood pressure within the mentioned range: * HbA1c 5.7 - 6.4% (pre-diabetes) * LDL 3.4 - 4.1 mmol L-¹ or TG \> 1.7 mmol L-¹ (atherogenesis) * hs-CRP 2 - 3 mg L-¹ (low-grade inflammation) * increase in BP or borderline BP (SBP 130 - 139 / DBP 85 - 89 mmHg) * availability of a smartphone and agrees that it can be used to connect the activity tracker to the internet and consent that data from the activity tracker will be uploaded and analyzed * Ability to communicate, read and write in German * Dietary tolerability of a Mediterranean diet (e.g. vegetables, olive oil, white meat, fish, plant-based proteins) * Ability to swallow supplement capsules Exclusion Criteria: * current smoking or vaping (smoker = More than 100 cigarettes or vapes in a life-time OR quitted less than 15 years ago and smoked more than 8 pack-years OR quitted less than 10 years ago and smoked max. 8 pack-years) * current supplementation with vitamin D and/or omega-3 and/or Fruitflow® and/or Centrum Silver® Adults 50+ multivitamin and/or taking any other multi-vitamin preparate and not willing to forgo during the trial duration * prior (ever used for more than 3 months) or current intake/application of metformin and/or GLP-1 and/or SGLT-2-inhibitor. * Current or recent (previous 12 months) participation in another clinical trial, or plans of such participation during participation in this trial * Presence of the following diagnosed health conditions in the last 4 years: * cancer (except non-melanoma skin cancer) * myocardial infarction, stroke, transient ischemic attack, angina pectoris, or coronary artery intervention * renal impairment and/or liver disease * relevant/severe impairment in mobility that leads to an inability to participate in the exercise component * major visual or hearing impairment * other serious illness that would preclude participation in the intervention components * Living together with another study participant
Where this trial is running
Basel, Canton of Basel-City
- Universitäre Altersmedizin Felix Platter — Basel, Canton of Basel-City, Switzerland (RECRUITING)
Study contacts
- Principal investigator: Heike A Bischoff-Ferrari, Prof. Dr. med., DrPH — Universitäre Altersmedizin Felix Platter
- Study coordinator: Heike A Bischoff-Ferrari, Prof. Dr. med., DrPH
- Email: ha.bischoff-ferrari@felixplatter.ch
- Phone: +41 61 326 40 22
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aging, pilot trial, accelerated aging, precision age, multimodal intervention