Precision medicine approach for managing pain and scoliosis

Precision Medicine for Nociception, Sngception and Proprioception.

This study is testing a personalized approach to pain management for people with myofascial pain syndrome and scoliosis to see if understanding their genetics can help find the best treatments for them.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 160 (estimated)
• Ages: 13 Years to 100 Years
• Sex: All
• Sponsor: National Taiwan University Hospital (Academic / other)
• Locations: 1 site (Taipei)
• Trial ID: NCT06161038 on ClinicalTrials.gov

What this trial studies

This study aims to utilize precision medicine to identify genetic variants that influence individual responses to pain treatments, specifically for conditions like myofascial pain syndrome and idiopathic scoliosis. By employing next-generation sequencing, the researchers will explore the genetic and molecular markers associated with pain perception and treatment efficacy. The goal is to develop a tailored treatment algorithm that can optimize pain management and reduce the time and costs associated with switching therapies. The study will involve interventions such as low-level laser therapy, ultrasound, and prolotherapy.

Who should consider this trial

Good fit: Ideal candidates include individuals aged 20-100 with myofascial pain syndrome or those aged 13-65 diagnosed with idiopathic scoliosis.

Not a fit: Patients with active infections, malignancies, or specific etiologies of scoliosis may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to more effective and personalized pain management strategies for patients.

How similar studies have performed: While precision medicine is a growing field, this specific approach to pain management through genetic markers is relatively novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

1.Cohort A:

(1) Age between 20-100 years old. (2) VAS\>=30 or VAS\>=30 at 4 kg pressure (3) Diagnosed as myofascial pain syndrome patients and willing to receive treatment (including LLLT, therapeutic ultrasound, and local dextrose injection therapy) 2. Cohort B:

1. Age between 13-65 years old.
2. Diagnosed as idiopathic scoliosis The diagnosis of scoliosis was confirmed by antero-posterior plain Xray with Cobbs angle larger than 10 degrees.

Exclusion Criteria:

1.Cohort A: Those having active infection, malignancy, and hematological diseases were excluded. The patients had received local injection at upper trapezius within 6 months are also excluded.

2.Cohort B:

1. Those having active infection, malignancy, and hematological diseases were excluded.
2. Those having specific etiologies of scoliosis, including congenital scoliosis due to malformation or faulty segmentation of the vertebrae and neuromuscular scoliosis due to muscular imbalance, syndromic scoliosis or degenerative scoliosis.
3. Pregnancy.

Where this trial is running

Taipei

• National Taiwan University Hospital Bei-Hu Branch — Taipei, Taiwan (Recruiting)

Study contacts

• Study coordinator: Der-Sheng Han, Physician

Conditions Rehabilitation; Pain, Shoulder; Pain, Chronic; Idiopathic Scoliosis; Sng / Pain; Precision medicine; Next generation sequencing; Proprioception