Precision medicine approach for heart failure management
Official title: Heart Failure Precision Medicine Study
Run by University of California, Davis · NCT04196842 · Data updated 2026-11-12
This study is testing a new way to personalize heart failure treatment by using advanced technology to better understand each patient's unique condition and improve their care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Sacramento, California) |
| Status | Recruiting |
| Started | October 16, 2019 |
| Main results expected | October 16, 2026 |
| Study ends | October 16, 2026 |
| Registry record updated | February 9, 2026 |
| Trial ID | NCT04196842 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with heart failure who have objective evidence of cardiac abnormalities and are in stages B-D and classes I-IV.
✕Probably not a fit
Patients unable to consent, those with significant comorbidities, or those who cannot comply with the study protocol may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how multi-omics profiling can identify specific heart failure profiles that are at risk for adverse outcomes. It aims to integrate clinical data with molecular information to enhance understanding of heart failure and improve treatment strategies. The study will recruit 1000 participants and utilize telemonitoring devices to optimize guideline-directed medical therapy. By employing longitudinal phenomapping and high-throughput molecular approaches, the study seeks to provide a comprehensive view of heart failure pathophysiology and treatment efficacy.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment strategies for patients with heart failure.
How similar studies have gone: Other studies utilizing multi-omics and precision medicine approaches have shown promise in improving outcomes for heart failure patients, indicating a potential for success in this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of Heart failure * Objective evidence of cardiac abnormality of structure or function (abnormal ECHO) or elevated levels of B-type natriuretic peptide (\>100 pg/ml) * HF stage B-D and class I-IV Exclusion Criteria: * Patients unable to consent * Inability to comply with the protocol and follow-up requirements * Patients unable to use a smartphone * Patients assessed irregularly (less than two visits in one year) * History of HTx * Use of Mechanical circulatory support device (MCSD) * Comorbidities that, according to the PI, have the potential to interfere with the interpretation of the results
Where it's running
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UC Davis Medical Center
Sacramento, California, United States Recruiting
Study contacts
- Principal investigator: Martin Cadeiras, MD — University of California, Davis
- Study coordinator: Erick S Romero, MD
- Email: esromero@ucdavis.edu
- Phone: (916) 703-2071
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using Apple Watch data to predict heart failure outcomes
This study is testing if data from Apple Watches can help predict heart failure problems and the chances of needing to go back to the hospital for patients with heart failure.
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This study is testing whether the Aortix device can help people with acute heart failure who aren't responding to diuretics feel better compared to standard treatment.
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Researchers are testing whether phosphorus-31 magnetic resonance spectroscopy (31P-MRS) can map heart energy metabolism across healthy people and patients with various heart conditions.
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Tailored digital support to cut sedentary time in long-term cardiac rehab
In adults in a long-term cardiac rehabilitation program, this study tests whether a personalized behavioural program with digital tools can reduce daily sitting time.
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NT-proBNP–guided heart failure screening for people 65+ in rural China
This study tests whether using NT-proBNP blood tests to guide heart failure screening in adults 65 and older in rural China can find unrecognized heart problems more effectively than symptom-based screening.
-
Voice-based detection of heart failure deterioration using Noah Labs Vox
This study tests whether a voice-analysis app can flag worsening heart failure in adults by comparing its alerts to standard weight-based monitoring.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.