Pre-op neutrophil-to-lymphocyte ratio and risk of headache after spinal anesthesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational analysis of obstetric patients who had cesarean delivery under spinal anesthesia, using preoperative complete blood counts to calculate the neutrophil-to-lymphocyte ratio (NLR). Researchers will compare NLR values between patients who did and did not develop post-dural puncture headache (PDPH) using medical record follow-up. Patients with hematologic or active inflammatory conditions, abnormal coagulation, or missing pre-op CBC data are excluded. Statistical models will control for key factors such as age, elective versus emergency procedure, and intraoperative events to see if higher NLR is associated with increased PDPH risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 years or older
* Underwent elective or emergency cesarean section under spinal anesthesia
* Had complete preoperative complete blood count (CBC) data available
* No known hematological or inflammatory disease
* No intraoperative complications recorded
* Medical records accessible for postoperative follow-up regarding PDPH symptoms

Exclusion Criteria:

* Age under 18
* Absence of preoperative complete blood count data
* Presence of hematologic malignancy, active infection, autoimmune disease, or immunosuppressive therapy
* Platelet count \<150,000/mm³ or INR \>1.5
* Incomplete or missing medical records

Where it's running

• Istinye Üniversity
  Istanbul, Merkez Mahallesi, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: ilke dolgun
• Email: ilkeser2004@gmail.com
• Phone: +905555485632

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Oral Gabapentin vs IV Neostigmine/Atropine vs Both for Preventing PDPH

  This study tests whether taking gabapentin by mouth, getting neostigmine with atropine by IV, or using both can help prevent postdural puncture headache after spinal anesthesia in pregnant patients.

  Recruiting Phase 2/3 Assiut University · Asyut · NCT07916116

• Restrictive versus liberal IV fluids during elective cesarean with spinal anesthesia

  This trial will test whether giving less versus more IV fluids during spinal anesthesia reduces nausea and speeds bowel recovery for women having an elective cesarean.

  Recruiting Nigde Omer Halisdemir University · Niğde, Merkez · NCT07440667

• Epidural hydroxyethyl starch to prevent post-dural puncture headache in parturients

  This study tests whether filling the epidural space with hydroxyethyl starch can help prevent post-dural puncture headaches in women who had an accidental dural puncture during epidural anesthesia for labor or cesarean delivery.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07914790

• Predicting Post-Dural Puncture Headache After Spinal Anesthesia in Cesarean Deliveries

  This study tests whether changes in optic nerve sheath diameter after spinal anesthesia can predict who will develop a post-dural puncture headache in pregnant women having an elective cesarean.

  Recruiting Ordu University · Ordu, Altinordu · NCT07729449

• Treating post-dural puncture headache with theophylline, sumatriptan, or gabapentin

  This trial will try theophylline, sumatriptan, and gabapentin to see which best relieves moderate-to-severe post-dural puncture headache in adults aged 21–50.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07515456

• Sphenopalatine ganglion block versus epidural blood patch for post-dural puncture headache

  This test compares a sphenopalatine ganglion block and an epidural blood patch to see which relieves post-dural puncture headaches better in adults whose pain hasn't improved after 24 hours of usual treatment.

  Recruiting Phase 3 University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07354464

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.