Pre-hospital wearable cooling after out-of-hospital cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

PRECEDENCE is a pilot feasibility trial led by Singapore General Hospital and the Singapore Civil Defence Force that tests initiating targeted temperature management in the field using a power-free CarbonCool® surface cooling vest after return of spontaneous circulation (ROSC). Eligible adult OHCA patients attended by SCDF paramedics who remain comatose after ROSC are allocated to pre-hospital cooling with the vest or to standard pre-hospital care based on predefined operational criteria. The trial measures feasibility, protocol fidelity, EMS provider acceptability, and safety, and follows participants through hospital admission to discharge. Findings will inform the design of a larger definitive trial to determine whether very early cooling improves neurological outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Out-of-hospital cardiac arrest (OHCA) of any rhythm attended by Singapore Civil Defence Force (SCDF) paramedics.
2. Return of spontaneous circulation (ROSC) achieved in the pre-hospital setting.
3. Age ≥16 years and ≤80 years.
4. Patient remains comatose after ROSC, with Glasgow Coma Scale (GCS) ≤8.

Exclusion Criteria:

1. Age \>80 years.
2. Traumatic cause of cardiac arrest.
3. Tympanic temperature \<34°C at time of assessment.
4. Pregnant females.
5. Termination of resuscitation in the Emergency Department.
6. Withdrawal of life support within 24 hours of Coronary Care Unit (CCU) admission.

Where it's running

• National University Heart Centre, Singapore (NUHCS)
  Singapore, Singapore Recruiting

Study contacts

• Study coordinator: Shir Lynn Lim, MBBS
• Email: shir.lynn.lim@nus.edu.sg
• Phone: +65 91760383

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.