Postural mobilization versus noradrenaline during off-pump coronary bypass

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

OPTICAB is a single-center randomized trial in Lyon comparing two hemodynamic management strategies during off‑pump coronary artery bypass grafting: postural mobilization (passive leg raising) with supplemental noradrenaline as needed versus noradrenaline alone. Patients are randomized intraoperatively and followed for 30 days to record vasopressor use, revascularization rates, and postoperative complications. The primary outcome is how often noradrenaline is required when passive leg raising is used as part of hemodynamic management. Secondary outcomes include perioperative hemodynamic parameters and postoperative clinical events over the 30‑day follow‑up.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient
* patient requiring isolated coronary bypass surgery
* Elective procedure or medical emergency
* First cardiac surgery
* Patient with an EF ≥30%
* Mandatory affiliation to a social security system
* Signed informed consent form
* Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure

Exclusion Criteria:

* Contraindication to an inotropic substance (only NA will be used)
* Contraindication to passive leg raising
* Patient in a life-threatening emergency
* History of cardiac surgery
* Bilateral iliac or common femoral artery occlusion
* EF \< 30%
* Pregnancy and breastfeeding
* Renal failure (GFR \< 40 ml/min/1.73 m²)
* Patient with bilateral thigh amputation
* Class III obesity BMI \> 40 kg/m²

Where it's running

• Infirmerie Protestante de Lyon
  Caluire-et-Cuire, Auvergne-Rhône-Alpes, France Recruiting

Study contacts

• Study coordinator: Siess
• Email: recherche-clinique@infirmerie-protestante.com
• Phone: +33 426297927

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.