Postprandial effects of fresh mango as a sugar substitute in high-sugar breakfasts
Official title: Effects of Fresh Mango as a Table Sugar Replacement on Postprandial Intestinal Permeability and Inflammation Following a High-Sugar Breakfast.
Run by Ball State University · NCT07650058 · Data updated 2026-11-12
This study tests whether using fresh mango instead of table sugar in a high-sugar breakfast lowers blood inflammation and gut permeability after eating, in healthy adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 35 (estimated) |
| Sponsor | Ball State University Academic / other |
| Locations | 1 site (Muncie, Indiana) |
| Status | Recruiting |
| Started | February 1, 2026 |
| Main results expected | July 2026 |
| Study ends | January 2027 |
| Registry record updated | June 16, 2026 |
| Trial ID | NCT07650058 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 18–45 with BMI 18.5–35 kg/m2, not pregnant, and without chronic medical conditions or relevant medication use.
✕Probably not a fit
Individuals with chronic diseases, pregnancy, pacemakers, or recent inflammatory or glucose-lowering medication use may not see benefit and may be excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants will consume two breakfast test meals in random order: corn flakes with milk plus fresh mango, and corn flakes with milk plus sucrose. Blood samples are taken at multiple time points after each meal to measure inflammatory and permeability biomarkers, including IL-6, LPS, LBP, and soluble CD14. The study uses banked serum from a prior randomized crossover trial and involves 35 adults with BMI 18.5–35 kg/m2. Meals are designed to be nearly isocaloric and matched for macronutrients, with identical total sugar content. The aim is to see if mango sugar substitution modulates postprandial inflammatory and gut barrier responses compared with sucrose.
Why it matters
Potential benefit: If successful, replacing sugar with mango could help reduce post-meal inflammation and gut permeability in the context of high-sugar diets.
How similar studies have gone: Previous research suggests fruit-derived sugars and bioactives can influence gut inflammation and permeability, but this specific mango-sugar substitution approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 - 45 years. * Body mass index between 18.5-35.0 kg/m2 * Not pregnant or expecting to become pregnant (females only) * Not postmenopausal (females only). * No known chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.) * No history of using tobacco/illicit drugs * No history of using glucose-lowering medications/supplements. * No history of using prescribed anti-inflammatory medications * Does not use over-the-counter anti-inflammatory medications ≥2x/week * Does not have a pacemaker. * No relevant food allergies/intolerances * Able to lay supine for at least ten minutes. Exclusion Criteria: * Not between the ages of 18-45 * Body mass index \< 18.5 kg/m2 or \>35.0 kg/m2 * Pregnant (females only) * Postmenopausal status (females only). * Been diagnosed with a chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.) * Uses tobacco products or any illicit drugs. * Uses glucose-lowering drugs/supplements. * Regularly takes anti-inflammatory drugs (more than 2x week). * Have a pacemaker. * Allergic to mango, wheat, gluten, and/or milk. * Unable to lay in supine position in the dark for at least ten minutes.
Where it's running
-
Health Professions Building, Ball State University
Muncie, Indiana, United States Recruiting
Study contacts
- Principal investigator: Bryant Keirns, PhD — Ball State University
- Study coordinator: Bryant Keirns, PhD
- Email: bryant.keirns@bsu.edu
- Phone: 765-285-8356
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.