Postpartum Furosemide for Better Blood Pressure After Severe Preeclampsia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, double-blind study, women with severe preeclampsia after delivery receive either furosemide 20 mg daily for 5 days or a placebo, in addition to standard postpartum blood pressure treatment. The trial monitors blood pressure, symptoms, adverse events, and need for additional antihypertensives for 7 days postpartum. Primary success is achieving two BP readings below 140/90 mmHg at least 48 hours apart without severe hypertension or increased antihypertensive needs through day 7. The study is conducted at Lady Reading Hospital in Peshawar, enrolling 434 participants (217 per arm). Patients are closely tracked to assess safety and efficacy of this add-on therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 to 45 years
* Any parity
* Gestational age \>28 weeks based on LMP
* Severe preeclampsia as per the study operational definition

Exclusion Criteria:

History of underlying cardiac disease during pregnancy or postpartum

* Pre-existing renal dysfunction or serum creatinine \>1.2 mg/dL on medical record
* Significant hypokalemia (K \<3 mEq/L) before enrollment
* Known rheumatologic disease or advanced diabetes
* History of allergy to furosemide or prior use of diuretics before randomization
* History of thyroid disorders or other medical illnesses that may interfere with blood pressure management

Where it's running

• Lady Reading Hospital
  Peshawar, Khyber Pakhtunkhwa, Pakistan Recruiting

Study contacts

• Principal investigator: Dr Qandil Sattar — Lady Reading Hospital Peshawar
• Study coordinator: Dr Qandil Sattar, MBBS
• Email: qantil.sattar@lrh.edu.pk
• Phone: +923436144247

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Postpartum Preeclampsia Care Using Point-of-Care Ultrasound and Diuretics

  The study tests whether using bedside ultrasound to guide diuretic therapy can improve outcomes for adults with preeclampsia after delivery.

  Recruiting Phase 4 University of California, Irvine · Orange, California · NCT07167862

• Aspirin with or without low‑molecular‑weight heparin to prevent preeclampsia in high‑risk pregnancy

  This trial tests whether adding low‑molecular‑weight heparin (tinzaparin) to low‑dose aspirin reduces the chance of preeclampsia in pregnant people identified as high risk in the first trimester.

  Recruiting Phase 4 Alexandra Hospital, Athens, Greece · Athens, Attica · NCT07361679

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.