Postoperative delirium after cardiac surgery: tracking risk factors and outcomes
Official title: A Real-World Single-Center Bidirectional Cohort Study on Postoperative Delirium in Patients Undergoing Cardiac Surgery
Run by Xijing Hospital · NCT07239648 · Data updated 2026-11-12
We will collect clinical and blood data from adults having elective heart surgery to see which preoperative factors predict postoperative delirium and whether delirium leads to worse long-term outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | Xijing Hospital Academic / other |
| Locations | 1 site (Xi'an, Shaanxi) |
| Status | Recruiting |
| Started | October 31, 2025 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | August 4, 2026 |
| Trial ID | NCT07239648 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 and older scheduled for elective cardiac surgery without pre-existing dementia or severe psychiatric illness are the intended participants.
✕Probably not a fit
Patients undergoing organ transplant or emergency operations, pregnant patients, and those with diagnosed dementia or major mental illness are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center bidirectional cohort will enroll adults undergoing elective cardiac surgery and build a follow-up database linking preoperative exposures, serum metabolic profiles, and postoperative delirium events. Researchers will analyze how preoperative factors relate to the incidence of delirium and, conversely, how delirium relates to longer-term outcomes such as prolonged ventilation, ICU stay, complications, cognitive decline, and mortality. The study excludes transplant surgeries, pregnant patients, and those with pre-existing dementia or major psychiatric illness. Data collection will include perioperative clinical variables, serum metabolomics, standardized delirium assessments during ICU recovery, and predefined follow-up visits.
Why it matters
Potential benefit: If successful, the project could help identify patients at high risk for delirium and enable earlier monitoring or preventive care to reduce complications and long-term decline.
How similar studies have gone: Previous observational studies have repeatedly linked postoperative delirium to longer ICU stays, increased complications, and worse long-term cognitive and survival outcomes, though robust predictive biomarkers and validated prognostic models are still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 18 years old and above 2. Patients undergoing elective cardiac surgery Exclusion Criteria: 1. Organ transplantation surgery 2. Pregnant patients 3. Diagnosed with dementia or mental illness (such as schizophrenia) before surgery
Where it's running
-
Xijing Hospital
Xi'an, Shaanxi, China Recruiting
Study contacts
- Study coordinator: Chong Lei, M.D.& phd
- Email: crystalleichong@126.com
- Phone: 18629011362
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.