Clinical trial Recruiting at 1 site Observational Ages 18 and up

Postoperative delirium after cardiac surgery: tracking risk factors and outcomes

Official title: A Real-World Single-Center Bidirectional Cohort Study on Postoperative Delirium in Patients Undergoing Cardiac Surgery

Run by Xijing Hospital · NCT07239648 · Data updated 2026-11-12

We will collect clinical and blood data from adults having elective heart surgery to see which preoperative factors predict postoperative delirium and whether delirium leads to worse long-term outcomes.

More Postoperative Delirium trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1500 (estimated)
SponsorXijing Hospital
Academic / other
Locations1 site (Xi'an, Shaanxi)
StatusRecruiting
StartedOctober 31, 2025
Main results expectedDecember 31, 2027
Study endsDecember 31, 2027
Registry record updatedAugust 4, 2026
Trial IDNCT07239648 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 and older scheduled for elective cardiac surgery without pre-existing dementia or severe psychiatric illness are the intended participants.

Probably not a fit

Patients undergoing organ transplant or emergency operations, pregnant patients, and those with diagnosed dementia or major mental illness are excluded and unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center bidirectional cohort will enroll adults undergoing elective cardiac surgery and build a follow-up database linking preoperative exposures, serum metabolic profiles, and postoperative delirium events. Researchers will analyze how preoperative factors relate to the incidence of delirium and, conversely, how delirium relates to longer-term outcomes such as prolonged ventilation, ICU stay, complications, cognitive decline, and mortality. The study excludes transplant surgeries, pregnant patients, and those with pre-existing dementia or major psychiatric illness. Data collection will include perioperative clinical variables, serum metabolomics, standardized delirium assessments during ICU recovery, and predefined follow-up visits.

Why it matters

Potential benefit: If successful, the project could help identify patients at high risk for delirium and enable earlier monitoring or preventive care to reduce complications and long-term decline.

How similar studies have gone: Previous observational studies have repeatedly linked postoperative delirium to longer ICU stays, increased complications, and worse long-term cognitive and survival outcomes, though robust predictive biomarkers and validated prognostic models are still limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. 18 years old and above
2. Patients undergoing elective cardiac surgery

Exclusion Criteria:

1. Organ transplantation surgery
2. Pregnant patients
3. Diagnosed with dementia or mental illness (such as schizophrenia) before surgery

Where it's running

  • Xijing Hospital
    Xi'an, Shaanxi, China
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.