Post‑ICU recovery after COVID‑19 lung failure in pregnant versus non‑pregnant patients
Post-intensive Care Syndromes in Pregnant Patients With Respiratory Failure and COVID-19 Compared to Non-pregnant Patients With Respiratory Failure and COVID-19
This project tries to see if adults who were pregnant during severe COVID‑19 lung failure recover differently after ICU care than adults who were not pregnant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Charite University, Berlin, Germany Academic / other |
| Locations | 1 site (Berlin) |
| Trial ID | NCT07051967 on ClinicalTrials.gov |
What this trial studies
This is a retrospective comparison of about 40 patients seen at the Charité PICS outpatient clinic between March 27, 2020 and May 6, 2024, including roughly 13 pregnant and 27 non‑pregnant patients who experienced COVID‑19–related respiratory failure. The analysis uses routine intensive care treatment records and outpatient PICS clinic data to describe clinical course and treatment outcomes over the course of follow‑up. Where available, additional data from nephrology, hepatology/gastroenterology, and infectiology/pulmonology services are incorporated. The goal is to characterize differences in recovery patterns, functional outcomes, and documented sequelae after ICU discharge.
Who should consider this trial
Good fit: Ideal candidates are adults admitted to a Charité ICU for COVID‑19–related lung failure between March 27, 2020 and May 6, 2024 who subsequently attended the Charité PICS outpatient clinic, with the pregnant group defined by pregnancy at the time of ICU admission.
Not a fit: People treated outside Charité, male patients, those without COVID‑19 or without respiratory failure, or those who did not attend the PICS clinic are not included and would not directly benefit from this analysis.
Why it matters
Potential benefit: If differences are identified, the findings could help tailor post‑ICU follow‑up and rehabilitation for pregnant patients recovering from severe COVID‑19.
How similar studies have performed: Previous studies have documented post‑intensive‑care syndrome after COVID‑19, but direct comparisons specifically between pregnant and non‑pregnant patients are limited, making this analysis relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18 years and older * Admission to a Charité intensive care unit and follow-up examination by the Post-Intensive-Care-Syndrome (PICS) outpatient clinic of the Department of Anesthesiology and Intensive Care Medicine between March 27, 2020 and May 6, 2024. * COVID-19 infection in temporal assocoation with the intensive care unit admission. * Intensive care unit admission with lung failure or development of lung failure in the course of intensive care unit treatment. * Admission to the intensive care unit with lung failure or development of lung failure during intensive care unit stay. Exclusion Criteria: * Gender: Male * Diagnosis: Non-COVID or no respiratory failure
Where this trial is running
Berlin
- Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin — Berlin, Germany (Recruiting)
Study contacts
- Study coordinator: Claudia Spies, MD Prof.
- Email: claudia.spies@charite.de
- Phone: +49 30 450 551102
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.