Post‑ICU recovery after COVID‑19 lung failure in pregnant versus non‑pregnant patients
Official title: Post-intensive Care Syndromes in Pregnant Patients With Respiratory Failure and COVID-19 Compared to Non-pregnant Patients With Respiratory Failure and COVID-19
Run by Charite University, Berlin, Germany · NCT07051967 · Data updated 2026-11-12
This project tries to see if adults who were pregnant during severe COVID‑19 lung failure recover differently after ICU care than adults who were not pregnant.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Charite University, Berlin, Germany Academic / other |
| Locations | 1 site (Berlin) |
| Status | Recruiting |
| Started | September 22, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT07051967 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults admitted to a Charité ICU for COVID‑19–related lung failure between March 27, 2020 and May 6, 2024 who subsequently attended the Charité PICS outpatient clinic, with the pregnant group defined by pregnancy at the time of ICU admission.
✕Probably not a fit
People treated outside Charité, male patients, those without COVID‑19 or without respiratory failure, or those who did not attend the PICS clinic are not included and would not directly benefit from this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective comparison of about 40 patients seen at the Charité PICS outpatient clinic between March 27, 2020 and May 6, 2024, including roughly 13 pregnant and 27 non‑pregnant patients who experienced COVID‑19–related respiratory failure. The analysis uses routine intensive care treatment records and outpatient PICS clinic data to describe clinical course and treatment outcomes over the course of follow‑up. Where available, additional data from nephrology, hepatology/gastroenterology, and infectiology/pulmonology services are incorporated. The goal is to characterize differences in recovery patterns, functional outcomes, and documented sequelae after ICU discharge.
Why it matters
Potential benefit: If differences are identified, the findings could help tailor post‑ICU follow‑up and rehabilitation for pregnant patients recovering from severe COVID‑19.
How similar studies have gone: Previous studies have documented post‑intensive‑care syndrome after COVID‑19, but direct comparisons specifically between pregnant and non‑pregnant patients are limited, making this analysis relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18 years and older * Admission to a Charité intensive care unit and follow-up examination by the Post-Intensive-Care-Syndrome (PICS) outpatient clinic of the Department of Anesthesiology and Intensive Care Medicine between March 27, 2020 and May 6, 2024. * COVID-19 infection in temporal assocoation with the intensive care unit admission. * Intensive care unit admission with lung failure or development of lung failure in the course of intensive care unit treatment. * Admission to the intensive care unit with lung failure or development of lung failure during intensive care unit stay. Exclusion Criteria: * Gender: Male * Diagnosis: Non-COVID or no respiratory failure
Where it's running
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Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin
Berlin, Germany Recruiting
Study contacts
- Study coordinator: Claudia Spies, MD Prof.
- Email: claudia.spies@charite.de
- Phone: +49 30 450 551102
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.