Post-incision antimicrobial washes to reduce C. acnes after shoulder replacement
Official title: Application of a Novel Antimicrobial Wash Versus Hydrogen Peroxide Versus Povidone-iodine to the Dermis and Incidence of Cutibacterium Acnes During Shoulder Arthroplasty: A Randomized Controlled Trial
Run by Henry Ford Health System · NCT06831422 · Data updated 2026-11-12
This trial will test whether applying different antimicrobial washes after the first incision lowers C. acnes growth in adults having primary shoulder replacement.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Henry Ford Health System Academic / other |
| Locations | 1 site (Detroit, Michigan) |
| Status | Recruiting |
| Started | May 5, 2025 |
| Main results expected | May 2027 |
| Study ends | December 2027 |
| Registry record updated | September 18, 2026 |
| Trial ID | NCT06831422 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (≥18) scheduled for primary shoulder arthroplasty for degenerative conditions who have failed at least six weeks of conservative treatment and have no prior shoulder infection or prior surgery on the affected shoulder.
✕Probably not a fit
Patients with prior native shoulder septic arthritis or prior surgery on the affected shoulder, active infection, cancer, autoimmune or rheumatologic disorders, proximal humerus fracture, or allergy to citric acid–derived products are excluded and would not be expected to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial assigns adults undergoing primary shoulder arthroplasty 1:1:1:1 to one of four post-incision approaches: Xperience Antimicrobial wash, 3% hydrogen peroxide, 10% povidone-iodine, or no post-incision treatment. Cultures are collected from the surgical site before incision, the incision after the initial cut, the shoulder joint, and room air, and are monitored daily for C. acnes for up to 18 days. Patients receive routine postoperative clinical evaluations of wound healing and complications at 2 weeks, 6 weeks, 3 months, 6 months, and 1 year, with data stored in a secure database and supplemented by electronic medical record review. Outcomes will compare rates of positive C. acnes cultures across the four groups to see if post-incision washes reduce contamination.
Why it matters
Potential benefit: If successful, this approach could lower C. acnes contamination and potentially reduce postoperative infection and related complications after shoulder replacement.
How similar studies have gone: Povidone-iodine and hydrogen peroxide have been used to reduce bacterial contamination in orthopedic procedures, but data specifically targeting C. acnes after shoulder arthroplasty are limited and the Xperience Antimicrobial wash represents a relatively novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Indicated and scheduled for primary shoulder arthroplasty. * Chronic severe glenohumeral osteoarthritis, avascular necrosis, post traumatic osteoarthritis, rotator cuff arthropathy, * Ability to read and understand English * Age ≥18 years * Patient failed ≥6 weeks of conservative treatment, which included non-steroidal anti-inflammatory drugs (NSAIDS) Exclusion Criteria: * Patient with history of prior native shoulder septic arthritis or infection * Prior surgery of affected shoulder * Proximal Humerus Fracture * Active infection * Cancer * Autoimmune and rheumatologic disorders, including rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus * History of allergic reaction to citric acid-derived products
Where it's running
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Henry Ford Health
Detroit, Michigan, United States Recruiting
Study contacts
- Study coordinator: Chimdindu Obinero, BS
- Email: cobiner1@hfhs.org
- Phone: 678-230-8592
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.