Portable markerless video system to measure walking in adults with neuromuscular conditions or healthy volunteers.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study uses a markerless gait-analysis system that records walking by video to quantify kinematic parameters without markers or large motion-capture rigs. Ambulatory adults aged 18–65 with genetically confirmed neuromuscular diseases (SMA, Charcot–Marie–Tooth, muscular dystrophy, myotonic dystrophy) and asymptomatic volunteers will perform standardized walking and functional tasks while being recorded. Researchers will extract gait parameters from the video and compare them to clinical measures to determine sensitivity to subtle biomechanical changes. The aim is to create a simple, clinic-compatible tool for monitoring gait in routine care and in clinical research.

Why it matters

Who can join: the full rules

* All volunteers

  * Age between 18 and 65
  * Ambulatory
  * Informed consent to participate in the study
  * Member of or beneficiary of a social security system
* Volunteers with a neuromuscular disease

  * Confirmed diagnosis of a neuromuscular disease of genetic origin (medical document to be provided upon enrollment in the study with proof of diagnosis) belonging to the list above.
  * Ability to walk for 2 minutes without assistance.
  * Ability to stand up from a chair with armrests at least 3 times in 30 seconds.
  * Ability to climb an inclined plane independently or with assistance to access the movement analysis room.

Exclusion Criteria

* All volunteers

  * Individuals under guardianship, curatorship, or legal protection
  * Pregnant or breastfeeding women
  * Non-ambulatory individuals
  * Individuals with epilepsy
  * Skin conditions preventing the placement of VICON motion sensors
* Asymptomatic volunteers

  * Unstable respiratory or cardiac problems
  * Neurological, musculoskeletal, or psychiatric problems
* Volunteers with a neuromuscular disease

  * Recent trauma or serious falls (≤ 6 months)
  * Individuals who have fallen more than twice in the past year and at least once in the past three months
  * Use of assistive devices such as rigid knee braces or walkers
  * Unstable cardiomyopathy
  * Individuals awaiting diagnosis

Exclusion criteria

* Inability to comply with the protocol requirements
* Medical or social conditions that could interfere with the study, as determined by the coordinating investigator or co-investigators.

Where it's running

• Centre d'Exploration et d'Évaluation Neuromusculaire
  Paris, France Recruiting

Study contacts

• Study coordinator: Pauline SANTMARTY, MsC
• Email: p.santmarty@institut-myologie.org
• Phone: +33 01 42 16 58 79

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.