Portable markerless video system to measure walking in adults with neuromuscular conditions or healthy volunteers.
Assessment of a Portable Digital Device for Quantified Analysis of Markerless Walking in Volunteers With Neuromuscular Diseases or Asymptomatic Volunteers
This project will test a portable video device that measures walking patterns to see if it can track gait changes in adults with neuromuscular diseases and in healthy volunteers.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Institut de Myologie, France Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT07321977 on ClinicalTrials.gov |
What this trial studies
The study uses a markerless gait-analysis system that records walking by video to quantify kinematic parameters without markers or large motion-capture rigs. Ambulatory adults aged 18–65 with genetically confirmed neuromuscular diseases (SMA, Charcot–Marie–Tooth, muscular dystrophy, myotonic dystrophy) and asymptomatic volunteers will perform standardized walking and functional tasks while being recorded. Researchers will extract gait parameters from the video and compare them to clinical measures to determine sensitivity to subtle biomechanical changes. The aim is to create a simple, clinic-compatible tool for monitoring gait in routine care and in clinical research.
Who should consider this trial
Good fit: Ideal candidates are ambulatory adults (18–65) with a confirmed genetic neuromuscular diagnosis listed in the protocol who can walk for two minutes, rise from a chair repeatedly, and access the movement analysis room, as well as healthy volunteers meeting the same age and mobility criteria.
Not a fit: Non-ambulatory individuals, people under 18 or over 65, pregnant or breastfeeding women, those with epilepsy, or those with skin conditions preventing motion capture are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, this could provide an easy clinic-friendly way to detect and track small changes in walking that help guide care and make clinical trials more efficient.
How similar studies have performed: Markerless gait analysis has shown promising results in research and pilot studies, but it remains relatively novel and not yet widely validated as a routine clinical biomarker.
Eligibility criteria
Show full inclusion / exclusion criteria
* All volunteers * Age between 18 and 65 * Ambulatory * Informed consent to participate in the study * Member of or beneficiary of a social security system * Volunteers with a neuromuscular disease * Confirmed diagnosis of a neuromuscular disease of genetic origin (medical document to be provided upon enrollment in the study with proof of diagnosis) belonging to the list above. * Ability to walk for 2 minutes without assistance. * Ability to stand up from a chair with armrests at least 3 times in 30 seconds. * Ability to climb an inclined plane independently or with assistance to access the movement analysis room. Exclusion Criteria * All volunteers * Individuals under guardianship, curatorship, or legal protection * Pregnant or breastfeeding women * Non-ambulatory individuals * Individuals with epilepsy * Skin conditions preventing the placement of VICON motion sensors * Asymptomatic volunteers * Unstable respiratory or cardiac problems * Neurological, musculoskeletal, or psychiatric problems * Volunteers with a neuromuscular disease * Recent trauma or serious falls (≤ 6 months) * Individuals who have fallen more than twice in the past year and at least once in the past three months * Use of assistive devices such as rigid knee braces or walkers * Unstable cardiomyopathy * Individuals awaiting diagnosis Exclusion criteria * Inability to comply with the protocol requirements * Medical or social conditions that could interfere with the study, as determined by the coordinating investigator or co-investigators.
Where this trial is running
Paris
- Centre d'Exploration et d'Évaluation Neuromusculaire — Paris, France (Recruiting)
Study contacts
- Study coordinator: Pauline SANTMARTY, MsC
- Email: p.santmarty@institut-myologie.org
- Phone: +33 01 42 16 58 79
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.