Polatuzumab with zanubrutinib, rituximab, lenalidomide and prednisone as first-line treatment for diffuse large B-cell lymphoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 2 trial gives a five-drug combination—polatuzumab vedotin, zanubrutinib, rituximab, lenalidomide, and prednisone—as induction therapy to adults with previously untreated diffuse large B-cell lymphoma. Patients will receive the regimen as their initial chemotherapy and be followed for overall response rate, progression-free survival, overall survival, and adverse events. Eligible participants are adults with pathologically confirmed DLBCL who have not had prior chemotherapy and meet standard safety criteria. The study is conducted at Navy General Hospital in Beijing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pathologically confirmed Diffuse Large B Cell Lymphoma according World Health Organization (WHO) classification;
* Patient is ≥ 18 years of age at the time of signing the informed consent form (ICF).
* Patient must understand and voluntarily sign an ICF prior to any study-specific assessments/procedures being conducted;
* Patient is willing and able to adhere to the study visit schedule and other protocol requirements;
* Patient has not received chemotherapy previously.
* Anticipated life expectancy at least 3 months

Exclusion Criteria:

* Active or uncontrolled infections requiring systemic treatment within 14 days before enrollment.
* Any instability of systemic disease, including but not limited to severe cardiac, liver, kidney, or metabolic disease need therapy.
* Pregnant or lactating women

Where it's running

• Navy General Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Liren Qian, PhD — Navy General Hospital, Beijing
• Study coordinator: Liren Qian, PhD
• Email: qlr2007@126.com
• Phone: +861066947194

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.