Pneumoperitoneum time and bicarbonate changes during laparoscopic inguinal hernia repair
Association Between Pneumoperitoneum Duration and Changes in Serum Bicarbonate Levels in Patients Undergoing Laparoscopic Inguinal Hernia Repair: A Prospective Observational Study
Haseki Training and Research Hospital · NCT07473583
This study will see if longer pneumoperitoneum time during laparoscopic inguinal hernia repair causes changes in blood bicarbonate levels in adults.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Haseki Training and Research Hospital (other) |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07473583 on ClinicalTrials.gov |
What this trial studies
This prospective observational study follows adults undergoing elective laparoscopic inguinal hernia repair with the TAPP technique to measure perioperative blood gas changes. Investigators will record the duration of carbon dioxide pneumoperitoneum and collect blood gas values, including serum bicarbonate, before surgery and two hours after surgery. The primary outcome is the change in bicarbonate (ΔHCO3-) between the preoperative and two-hour postoperative measurements, with secondary outcomes of pH, pCO2, postoperative pain scores, and early complications within 24 hours. Analysis will test whether longer pneumoperitoneum duration is associated with greater shifts in acid-base parameters.
Who should consider this trial
Good fit: Adults aged 18 or older scheduled for elective laparoscopic inguinal hernia repair using the TAPP technique who can provide informed consent are ideal candidates.
Not a fit: Patients with exclusions such as pregnancy, severe cardiovascular disease, renal insufficiency, additional intra-abdominal procedures, or strangulated hernia needing bowel resection may not benefit and, as an observational study, most participants should not expect direct clinical benefit.
Why it matters
Potential benefit: If a link is found, the results could help anesthesiologists and surgeons adjust perioperative care to reduce metabolic disturbances during laparoscopic hernia repair.
How similar studies have performed: Previous work has shown that CO2 pneumoperitoneum can alter pH and pCO2, but the specific relationship between pneumoperitoneum duration and serum bicarbonate changes is less well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Patients undergoing laparoscopic inguinal hernia repair using the TAPP technique * Ability to provide informed consent Exclusion Criteria: * Pregnancy * Severe cardiovascular disease * Renal insufficiency * Patients requiring additional intra-abdominal surgical procedures * Strangulated inguinal hernia requiring bowel resection
Where this trial is running
Istanbul
- Haseki Training and Research Hospital — Istanbul, Turkey (Türkiye) (RECRUITING)
Study contacts
- Principal investigator: Muzaffer Akinci, MD — Haseki Training and Research Hospital
- Study coordinator: Osman Sibic, MD
- Email: osmansibic@gmail.com
- Phone: +90 534 617 72 53
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hernia, Inguinal, Inguinal Hernia, Pneumoperitoneum, Laparoscopic Inguinal Hernia Repair, Serum Bicarbonate, Blood Gas Analysis, TAPP Technique