Clinical trial Recruiting at 1 site Observational Ages 18 and up

Pneumoperitoneum time and bicarbonate changes during laparoscopic inguinal hernia repair

Official title: Association Between Pneumoperitoneum Duration and Changes in Serum Bicarbonate Levels in Patients Undergoing Laparoscopic Inguinal Hernia Repair: A Prospective Observational Study

Run by Haseki Training and Research Hospital · NCT07473583 · Data updated 2026-11-12

This study will see if longer pneumoperitoneum time during laparoscopic inguinal hernia repair causes changes in blood bicarbonate levels in adults.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorHaseki Training and Research Hospital
Academic / other
Locations1 site (Istanbul)
StatusRecruiting
StartedMarch 10, 2026
Main results expectedApril 2026
Study endsMay 2026
Registry record updatedMarch 16, 2026
Trial IDNCT07473583 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 or older scheduled for elective laparoscopic inguinal hernia repair using the TAPP technique who can provide informed consent are ideal candidates.

Probably not a fit

Patients with exclusions such as pregnancy, severe cardiovascular disease, renal insufficiency, additional intra-abdominal procedures, or strangulated hernia needing bowel resection may not benefit and, as an observational study, most participants should not expect direct clinical benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study follows adults undergoing elective laparoscopic inguinal hernia repair with the TAPP technique to measure perioperative blood gas changes. Investigators will record the duration of carbon dioxide pneumoperitoneum and collect blood gas values, including serum bicarbonate, before surgery and two hours after surgery. The primary outcome is the change in bicarbonate (ΔHCO3-) between the preoperative and two-hour postoperative measurements, with secondary outcomes of pH, pCO2, postoperative pain scores, and early complications within 24 hours. Analysis will test whether longer pneumoperitoneum duration is associated with greater shifts in acid-base parameters.

Why it matters

Potential benefit: If a link is found, the results could help anesthesiologists and surgeons adjust perioperative care to reduce metabolic disturbances during laparoscopic hernia repair.

How similar studies have gone: Previous work has shown that CO2 pneumoperitoneum can alter pH and pCO2, but the specific relationship between pneumoperitoneum duration and serum bicarbonate changes is less well established.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥18 years
* Patients undergoing laparoscopic inguinal hernia repair using the TAPP technique
* Ability to provide informed consent

Exclusion Criteria:

* Pregnancy
* Severe cardiovascular disease
* Renal insufficiency
* Patients requiring additional intra-abdominal surgical procedures
* Strangulated inguinal hernia requiring bowel resection

Where it's running

  • Haseki Training and Research Hospital
    Istanbul, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.