Pneumoperitoneum time and bicarbonate changes during laparoscopic inguinal hernia repair
Official title: Association Between Pneumoperitoneum Duration and Changes in Serum Bicarbonate Levels in Patients Undergoing Laparoscopic Inguinal Hernia Repair: A Prospective Observational Study
Run by Haseki Training and Research Hospital · NCT07473583 · Data updated 2026-11-12
This study will see if longer pneumoperitoneum time during laparoscopic inguinal hernia repair causes changes in blood bicarbonate levels in adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Haseki Training and Research Hospital Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | March 10, 2026 |
| Main results expected | April 2026 |
| Study ends | May 2026 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT07473583 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older scheduled for elective laparoscopic inguinal hernia repair using the TAPP technique who can provide informed consent are ideal candidates.
✕Probably not a fit
Patients with exclusions such as pregnancy, severe cardiovascular disease, renal insufficiency, additional intra-abdominal procedures, or strangulated hernia needing bowel resection may not benefit and, as an observational study, most participants should not expect direct clinical benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study follows adults undergoing elective laparoscopic inguinal hernia repair with the TAPP technique to measure perioperative blood gas changes. Investigators will record the duration of carbon dioxide pneumoperitoneum and collect blood gas values, including serum bicarbonate, before surgery and two hours after surgery. The primary outcome is the change in bicarbonate (ΔHCO3-) between the preoperative and two-hour postoperative measurements, with secondary outcomes of pH, pCO2, postoperative pain scores, and early complications within 24 hours. Analysis will test whether longer pneumoperitoneum duration is associated with greater shifts in acid-base parameters.
Why it matters
Potential benefit: If a link is found, the results could help anesthesiologists and surgeons adjust perioperative care to reduce metabolic disturbances during laparoscopic hernia repair.
How similar studies have gone: Previous work has shown that CO2 pneumoperitoneum can alter pH and pCO2, but the specific relationship between pneumoperitoneum duration and serum bicarbonate changes is less well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Patients undergoing laparoscopic inguinal hernia repair using the TAPP technique * Ability to provide informed consent Exclusion Criteria: * Pregnancy * Severe cardiovascular disease * Renal insufficiency * Patients requiring additional intra-abdominal surgical procedures * Strangulated inguinal hernia requiring bowel resection
Where it's running
-
Haseki Training and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Muzaffer Akinci, MD — Haseki Training and Research Hospital
- Study coordinator: Osman Sibic, MD
- Email: osmansibic@gmail.com
- Phone: +90 534 617 72 53
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.