Platinum chemotherapy and hearing in cancer patients from deprived communities
Official title: Chemotherapy-Induced Hearing Loss and Health Inequality
Run by Lancaster University · NCT07553481 · Data updated 2026-11-12
This study tests how platinum-based chemotherapy affects hearing in cancer patients living in the North West of England and whether socioeconomic deprivation influences risk.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 172 (estimated) |
| Sponsor | Lancaster University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Lancaster, Lancashire) |
| Status | Recruiting |
| Started | May 2, 2026 |
| Main results expected | September 1, 2028 |
| Study ends | September 1, 2028 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT07553481 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults in North West England receiving platinum-based chemotherapy, able to complete online tests, and fluent in English.
✕Probably not a fit
Patients who are not treated with platinum-based chemotherapy or who do not meet the online testing requirements may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study examines hearing changes in cancer patients treated with platinum-based chemotherapy, focusing on how deprivation status may relate to risk. It will collect hearing and cognitive test results, along with demographic and health information, to understand patterns of hearing loss. The goal is to inform future care by identifying whether disadvantaged groups experience greater burden and whether screening or support needs differ by socioeconomic status.
Why it matters
Potential benefit: If successful, findings could guide targeted screening and supportive care to reduce communication difficulties for patients at higher risk of hearing loss.
How similar studies have gone: Previous work has documented ototoxicity from platinum agents, but this project adds a health inequity dimension that is less explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients receiving platinum-based chemotherapy drugs * Living and treated within North West England * Able to complete an online hearing and cognitive test * Fluent in English Exclusion Criteria: * Following cancer types: brain tumour/metastasis, head + neck, skin cancers around the ear, and adenoid cystic carcinoma of the auditory cortex * World Health Organisation performance status score of 3 or more * Stage 4 cancer * History of childhood deafness * Current or recent ear infections * Cochlear implant user * Known neurological impairment (e.g., stroke, traumatic brain injury, dementia) * Patients who look capacity to consent or complete study tasks
Where it's running
-
Lancaster University
Lancaster, Lancashire, United Kingdom Recruiting
Study contacts
- Study coordinator: Helen Nuttall
- Email: h.nuttall1@lancaster.ac.uk
- Phone: 01524 592842
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.