Platelets and HIV Reservoirs: A look at how platelets might harbor HIV in people living with HIV
Official title: PLAQUAGE - Platelets Target the Circulating HIV Reservoir: Implications for Immunological Failure
Run by Tourcoing Hospital · NCT07745530 · Data updated 2026-11-12
This observational study tests whether HIV can be found inside platelets in adults with suppressed HIV on therapy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Tourcoing Hospital Academic / other |
| Locations | 1 site (Tourcoing) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | October 1, 2026 |
| Study ends | October 1, 2026 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT07745530 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults living with HIV who have had an undetectable viral load for more than two years and can provide informed consent.
✕Probably not a fit
Individuals without detectable HIV reservoirs in platelets or those not meeting the specific inclusion criteria may not see a direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study examines the potential interaction between HIV reservoirs and platelets in people living with HIV who have had an undetectable viral load for more than two years. Blood samples are used to identify whether platelets carry HIV and to understand how this might influence latency and viral persistence. The approach does not involve an intervention beyond sampling and observational analysis. Results could help clarify whether platelets play a role in maintaining proviral DNA within reservoirs. The study is conducted at Tourcoing, France, led by Tourcoing Hospital with local collaboration only.
Why it matters
Potential benefit: If platelets are found to harbor HIV, this could guide future research on reservoir biology and latency reversal strategies.
How similar studies have gone: Previous work has explored HIV reservoirs in various cell types, with some evidence suggesting platelets could interact with HIV, but this specific approach remains exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients living with HIV with an undetectable viral load for more than 2 years * Beneficiary of a social security scheme or rightful claimant; * Patients able to read and understand the information sheet; * Having signed the consent form. Exclusion Criteria: * being unable to give free and informed consent; * pregnant or breastfeeding woman; * being under guardianship, curatorship, or a protection mandate;
Where it's running
-
Centre Hospitalier de Tourcoing
Tourcoing, France Recruiting
Study contacts
- Principal investigator: Olivier Robineau, MD, PhD — Centre Hospitalier de Tourcoing
- Study coordinator: Jean-Jacques VITAGLIANO, PhD
- Email: jjvitagliano@ch-tourcoing.fr
- Phone: +33320694280
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.