Platelet-rich plasma treatment for patellar, Achilles, elbow (epicondylitis), and plantar heel tendinopathies.
Multicenter Real-World Evidence (RWE) Study: Evaluation of Platelet-Rich Plasma (PRP) Treatment in Tendinopathies
This multicenter observational project will try platelet-rich plasma (PRP) injections to see if they reduce pain and improve function in adults with chronic patellar, Achilles, lateral elbow (epicondylitis), or plantar heel (fasciitis) tendinopathies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | ReSport Clinic Academic / other |
| Locations | 5 sites (A Coruña and 4 other locations) |
| Trial ID | NCT07558564 on ClinicalTrials.gov |
What this trial studies
This is a prospective, multicenter, real-world evidence cohort collecting data on PRP treatment for four common tendinopathies. Participating centers will record clinical variables, treatment protocols, and outcomes over 12 months while characterizing PRP preparations using hematology analyzers and the BioSmartData® platform. The design is observational, so treatments follow routine clinical practice rather than a randomized protocol. Adults with chronic (>6 weeks) tendon symptoms who can consent and complete follow-up are eligible, while recent surgery, recent corticosteroid injection, systemic inflammatory disease, coagulopathy/anticoagulant use, low platelet counts, pregnancy, or breastfeeding are exclusions.
Who should consider this trial
Good fit: Adults (age >18) with a clinical or ultrasound diagnosis of chronic patellar, Achilles, lateral epicondylitis, or plantar fasciitis who can give informed consent and complete 12 months of follow-up and have a platelet count ≥100 × 10⁹/L.
Not a fit: Patients with recent tendon surgery, corticosteroid injection within the last month, systemic inflammatory disease, coagulopathy or anticoagulant therapy, low platelet counts, or who are pregnant or breastfeeding are excluded and unlikely to receive benefit under this protocol.
Why it matters
Potential benefit: If successful, PRP could offer a minimally invasive option that reduces pain and improves function for people with chronic tendinopathies.
How similar studies have performed: Previous randomized trials and meta-analyses report mixed results for PRP in tendinopathies, with some positive findings for lateral epicondylitis and plantar fasciitis but inconsistent outcomes for Achilles and patellar tendons.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical and/or ultrasound diagnosis of chronic tendinopathy (duration \>6 weeks) * Age \>18 years * Provision of written informed consent * Willingness and ability to complete follow-up assessments for 12 months Exclusion Criteria: * Surgical treatment of the affected tendon within the previous 6 months * Corticosteroid injection within the last month * Systemic inflammatory disease (e.g., rheumatoid arthritis) * Coagulopathies or ongoing anticoagulant therapy * Complete blood count showing a platelet concentration \<100 × 10⁹/L (to exclude patients with potential thrombocytopenia) * Pregnancy or breastfeeding
Where this trial is running
A Coruña and 4 other locations
- Instituto Médico Arriaza — A Coruña, Spain (Recruiting)
- Instituto Cugat — Barcelona, Spain (Recruiting)
- ReSport Clinic — Barcelona, Spain (Recruiting)
- Ripoll y dePrado Medical Group — Madrid, Spain (Recruiting)
- Hospital MIKS — Vitoria-Gasteiz, Spain (Recruiting)
Study contacts
- Principal investigator: Ferran Abat Gonzalez, MD PhD — ReSport Clinic
- Study coordinator: Resport Clinic, MD PhD
- Email: abat@resportclinic.com
- Phone: +34 93 2778709
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.