Platelet-rich plasma (PRP) injection to improve voice recovery after benign vocal fold surgery
Evaluating The Efficacy of Platelet Rich Plasma on Voice Outcomes Following Surgical Removal of Benign Vocal Fold Lesions
This trial will try injecting platelet-rich plasma (PRP) into the operated vocal fold after microlaryngoscopic removal of benign lesions to see if adults recover voice quality faster and have less vocal fatigue.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 64 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Beni-Suef University Academic / other |
| Locations | 1 site (Banī Suwayf, Egypt) |
| Trial ID | NCT07300800 on ClinicalTrials.gov |
What this trial studies
This interventional study enrolls adults aged 18–50 undergoing microlaryngosurgery for benign vocal fold lesions and allocates them to receive either a postoperative PRP injection to the operated vocal fold or conventional postoperative care. A total of 64 participants are divided into two groups of 32 and undergo baseline voice testing before surgery with follow-up assessments at 1 and 3 months. Outcome measures include perceptual voice rating (GRBAS), videostroboscopy, acoustic and aerodynamic analyses, and the Vocal Fatigue Index. The trial is conducted at Beni Suef University Hospital in Banī Suwayf, Egypt.
Who should consider this trial
Good fit: Adults aged 18 to 50 who are scheduled for microlaryngoscopic removal of benign vocal fold lesions (polyps, cysts, or nodules) after failing conservative management are the ideal candidates.
Not a fit: Patients outside the 18–50 age range, those medically unfit for surgery, those with malignant or non-lesion causes of dysphonia, or those managed without surgery are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, PRP injections could speed recovery of voice quality and reduce vocal fatigue after surgery, improving patients' daily communication and quality of life.
How similar studies have performed: Small clinical series and preclinical work have suggested PRP may aid vocal fold healing, but high-quality randomized evidence is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
* Inclusion Criteria: \* Adults aged 18 to 50 years \* Diagnosis of a benign vocal fold lesion, including: Vocal fold polyps Vocal fold cysts Vocal fold nodules \* Failure to respond to conservative management, including one or more of the following: Voice rest, voice therapy * Exclusion Criteria: * Age younger than 18 years or above 50 * Medically unfit for surgery
Where this trial is running
Banī Suwayf, Egypt
- Beni Suef Univesity hospital — Banī Suwayf, Egypt, Egypt (Recruiting)
Study contacts
- Principal investigator: Shaimaa Ahmed Bakia — Lecturer of Phoniatrics
- Study coordinator: Shaimaa Bakia, Lecturer
- Email: shaimaa.saleh@med.bsu.edu.eg
- Phone: +201145335408
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.