Platelet-rich plasma (PRP) injection to improve voice recovery after benign vocal fold surgery
Official title: Evaluating The Efficacy of Platelet Rich Plasma on Voice Outcomes Following Surgical Removal of Benign Vocal Fold Lesions
Run by Beni-Suef University · NCT07300800 · Data updated 2026-11-12
This trial will try injecting platelet-rich plasma (PRP) into the operated vocal fold after microlaryngoscopic removal of benign lesions to see if adults recover voice quality faster and have less vocal fatigue.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 64 (estimated) |
| Sponsor | Beni-Suef University Academic / other |
| Locations | 1 site (Banī Suwayf, Egypt) |
| Status | Recruiting |
| Started | March 4, 2025 |
| Main results expected | May 29, 2026 |
| Study ends | July 30, 2026 |
| Registry record updated | June 1, 2026 |
| Trial ID | NCT07300800 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 to 50 who are scheduled for microlaryngoscopic removal of benign vocal fold lesions (polyps, cysts, or nodules) after failing conservative management are the ideal candidates.
✕Probably not a fit
Patients outside the 18–50 age range, those medically unfit for surgery, those with malignant or non-lesion causes of dysphonia, or those managed without surgery are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study enrolls adults aged 18–50 undergoing microlaryngosurgery for benign vocal fold lesions and allocates them to receive either a postoperative PRP injection to the operated vocal fold or conventional postoperative care. A total of 64 participants are divided into two groups of 32 and undergo baseline voice testing before surgery with follow-up assessments at 1 and 3 months. Outcome measures include perceptual voice rating (GRBAS), videostroboscopy, acoustic and aerodynamic analyses, and the Vocal Fatigue Index. The trial is conducted at Beni Suef University Hospital in Banī Suwayf, Egypt.
Why it matters
Potential benefit: If successful, PRP injections could speed recovery of voice quality and reduce vocal fatigue after surgery, improving patients' daily communication and quality of life.
How similar studies have gone: Small clinical series and preclinical work have suggested PRP may aid vocal fold healing, but high-quality randomized evidence is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
* Inclusion Criteria: \* Adults aged 18 to 50 years \* Diagnosis of a benign vocal fold lesion, including: Vocal fold polyps Vocal fold cysts Vocal fold nodules \* Failure to respond to conservative management, including one or more of the following: Voice rest, voice therapy * Exclusion Criteria: * Age younger than 18 years or above 50 * Medically unfit for surgery
Where it's running
-
Beni Suef Univesity hospital
Banī Suwayf, Egypt, Egypt Recruiting
Study contacts
- Principal investigator: Shaimaa Ahmed Bakia — Lecturer of Phoniatrics
- Study coordinator: Shaimaa Bakia, Lecturer
- Email: shaimaa.saleh@med.bsu.edu.eg
- Phone: +201145335408
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.