Platelet-rich fibrin (PRF) gel for chronic leg ulcers
Efficacy of Platelet-rich-Fibrin Gel in Patients With Chronic Leg Ulcers
This will try platelet-rich fibrin (PRF) gel dressings to see if they help heal non-infected chronic leg ulcers in adults over 35.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 35 Years and up |
| Sex | All |
| Sponsor | Pak Emirates Military Hospital Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Trial ID | NCT07294521 on ClinicalTrials.gov |
What this trial studies
This early-phase interventional study will apply autologous platelet-rich fibrin (PRF) gel dressings to patients with non-infected chronic leg ulcers and follow wound healing over time. Wound severity and treatment response will be measured using the Bates-Jensen Wound Assessment Tool (BWAT) at scheduled visits. Eligible participants are adults older than 35, while those with infected ulcers, sepsis, or immunosuppression are excluded. The trial is single-center and conducted at Pak Emirates Military Hospital in Rawalpindi.
Who should consider this trial
Good fit: Adults over 35 with non-infected chronic leg ulcers who can attend regular outpatient visits and are not immunosuppressed are the intended participants.
Not a fit: Patients with clinically infected ulcers, sepsis, or who are immunosuppressed are excluded and unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, PRF gel dressings could speed ulcer healing, reduce pain and mobility loss, and decrease the need for prolonged wound care.
How similar studies have performed: Small case series and early clinical reports suggest PRF can promote healing in chronic wounds, but high-quality randomized data are still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All male and female patients more than 35 years old with Chronic Leg Ulcers, presenting to the OPD will be included. Exclusion Criteria: * Patients with clinical signs of infected ulcers, patients in sepsis and immunosuppressed individuals will be excluded.
Where this trial is running
Rawalpindi, Punjab Province
- Pak Emirates Military Hospital — Rawalpindi, Punjab Province, Pakistan (Recruiting)
Study contacts
- Principal investigator: Prof. Moizza Tahir, MBBS, FCPS, FRCP — Pak Emirates Military Hospital
- Study coordinator: Ahsan Tameez Ud Din, MBBS
- Email: ahsantameezuddinmalik@gmail.com
- Phone: (+92 051) 9273480
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.