Clinical trial Recruiting at 1 site Observational Ages 18 and up

Plasma D-dimer and severity in adult community-acquired pneumonia

Official title: Association Between Elevated Plasma D-dimer in Adult Community-acquired Pneumonia Patients and Severity of Inflammatory Response and Survival

Run by Ain Shams University · NCT07199530 · Data updated 2026-11-12

This project will see if higher blood D-dimer levels are linked to stronger inflammation and worse survival in adults with community-acquired pneumonia.

More D-dimer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorAin Shams University
Academic / other
Locations1 site (Cairo)
StatusRecruiting
StartedMarch 23, 2025
Main results expectedMarch 2026
Study endsApril 2026
Registry record updatedFebruary 24, 2026
Trial IDNCT07199530 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 or older with clinically and radiologically confirmed community-acquired pneumonia seen or admitted to Ain Shams University Hospitals who do not have signs of COVID-19 and consent to blood sampling are ideal candidates.

Probably not a fit

Patients with known coagulation disorders, active cancer, other chronic diseases, or clinical or radiologic signs of COVID-19 are excluded and thus unlikely to benefit from this study's findings.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll at least 50 adults with community-acquired pneumonia seen or admitted to Ain Shams University Hospitals in Cairo. Investigators will collect blood for plasma D-dimer and routine labs (white blood cell count, CRP), obtain chest x-rays, and calculate CURB-65 severity scores. The analysis will examine relationships between D-dimer levels, markers of inflammatory response, clinical severity scores, and survival. Patients with coagulation disorders, active cancer, other chronic diseases, or signs of COVID-19 will be excluded and no experimental treatments are administered.

Why it matters

Potential benefit: If successful, measuring D-dimer could help clinicians estimate illness severity and survival risk in CAP and inform treatment decisions.

How similar studies have gone: Previous studies have often reported that higher D-dimer levels correlate with worse outcomes in pneumonia, so this approach has supporting evidence though findings are not entirely consistent.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients who will be admitted to the Chest department, or coming to the outpatient clinic at Ain-Shams University Hospitals with CAP, and have the following inclusions:

  1. age ≥18 years
  2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.

Exclusion Criteria:

* Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
* patients who have any clinical or radiological signs suggesting COVID-19 pneumonia.

Where it's running

  • Ain Shams University hospitals
    Cairo, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.