Plasma D-dimer and severity in adult community-acquired pneumonia
Official title: Association Between Elevated Plasma D-dimer in Adult Community-acquired Pneumonia Patients and Severity of Inflammatory Response and Survival
Run by Ain Shams University · NCT07199530 · Data updated 2026-11-12
This project will see if higher blood D-dimer levels are linked to stronger inflammation and worse survival in adults with community-acquired pneumonia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | March 23, 2025 |
| Main results expected | March 2026 |
| Study ends | April 2026 |
| Registry record updated | February 24, 2026 |
| Trial ID | NCT07199530 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with clinically and radiologically confirmed community-acquired pneumonia seen or admitted to Ain Shams University Hospitals who do not have signs of COVID-19 and consent to blood sampling are ideal candidates.
✕Probably not a fit
Patients with known coagulation disorders, active cancer, other chronic diseases, or clinical or radiologic signs of COVID-19 are excluded and thus unlikely to benefit from this study's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will enroll at least 50 adults with community-acquired pneumonia seen or admitted to Ain Shams University Hospitals in Cairo. Investigators will collect blood for plasma D-dimer and routine labs (white blood cell count, CRP), obtain chest x-rays, and calculate CURB-65 severity scores. The analysis will examine relationships between D-dimer levels, markers of inflammatory response, clinical severity scores, and survival. Patients with coagulation disorders, active cancer, other chronic diseases, or signs of COVID-19 will be excluded and no experimental treatments are administered.
Why it matters
Potential benefit: If successful, measuring D-dimer could help clinicians estimate illness severity and survival risk in CAP and inform treatment decisions.
How similar studies have gone: Previous studies have often reported that higher D-dimer levels correlate with worse outcomes in pneumonia, so this approach has supporting evidence though findings are not entirely consistent.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who will be admitted to the Chest department, or coming to the outpatient clinic at Ain-Shams University Hospitals with CAP, and have the following inclusions: 1. age ≥18 years 2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence. Exclusion Criteria: * Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate. * patients who have any clinical or radiological signs suggesting COVID-19 pneumonia.
Where it's running
-
Ain Shams University hospitals
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Hieba Gamal Ezzelregal
- Email: hiebagamal24@med.asu.edu.eg
- Phone: +201002041611
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.