Plant-based protein sauce to improve amino acid absorption without excess fullness in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized crossover test compares a plant-based, protein-dense sauce (ProSauce) with a commercially available low-protein sauce in community-dwelling adults aged 60 and over. Participants consume each meal in random order with at least a one-week washout and provide venous blood samples over a six-hour postprandial period to measure plasma essential and non-essential amino acids and insulin. The study also records subjective gut fullness and satiety to see if the liquid high-protein format suppresses appetite. Individuals with medical conditions or medications that could affect metabolism are excluded to isolate the effect of the sauces.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 60 and over
* Living independently in the community
* Capacity to provide informed consent
* Non-smoking (vaping is considered smoking)
* No known medical conditions that might influence the study outcomes, e.g., heart disease, diabetes mellitus, obesity, disthyroidism and other endocrinopathies and renal failure
* Not taking any medications that might influence the study outcomes e.g., taking anabolic steroids or corticosteroids long term
* No clinically diagnosed eating disorders
* No severe dislike or allergy to any of the study food
* No hospitalisations in the last 6 months
* Not dieting and weight stable for 3 months before the study (\< 3 kg change in weight)

Exclusion Criteria:

* Age \< 60y
* Smoking
* Food allergies
* Cognitive and mobility issues
* Hospitalisation in the last 6 months
* Known medical conditions that might influence the study outcomes
* Taking medications that influence the study outcomes

Where it's running

• University of Exeter
  Exeter, Devon, United Kingdom Recruiting

Study contacts

• Principal investigator: Joanna Bowtell, Prof — University of Exeter
• Study coordinator: Zhuoxiu Jin, Dr
• Email: z.jin3@exeter.ac.uk
• Phone: +447529283410

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.