Placental characteristics in monochorionic twins
Placental Characteristics Within Monochorionic Twin Pregnancies: a Prospective Cohort Study.
Birmingham Women's NHS Foundation Trust · NCT07124312
This project will see how placental anatomy relates to outcomes for families with monochorionic twins by analyzing placentas after birth at a Birmingham NHS site.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 65 (estimated) |
| Sex | Female |
| Sponsor | Birmingham Women's NHS Foundation Trust (other gov) |
| Locations | 1 site (Birmingham, West Midlands) |
| Trial ID | NCT07124312 on ClinicalTrials.gov |
What this trial studies
This prospective, single-site observational project will recruit people carrying monochorionic twin pregnancies during the antenatal period and obtain consent for placental analysis after delivery. All placentas transferred to the pathology department will be examined macroscopically and key anatomical features will be recorded. These placental findings will be compared with antenatal complications and perinatal outcomes for each twin pair. The goal is to build a comprehensive database to better understand how placental architecture may inform antenatal care.
Who should consider this trial
Good fit: Ideal candidates are people pregnant with monochorionic twins who consent antenatally and deliver at the site such that the placenta can be transferred to the pathology department for analysis.
Not a fit: Patients with singleton, dichorionic, higher-order pregnancies, major fetal anomalies or aneuploidy, or those who do not deliver at the recruiting site are not eligible and would not benefit from this project.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor antenatal surveillance based on placental anatomy and potentially improve perinatal outcomes for monochorionic twins.
How similar studies have performed: Previous placental pathology studies have linked placental anatomy to outcomes in twin pregnancies, but a prospective, comprehensive UK cohort focusing on all monochorionic placentas at a single center is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • All consecutive placentas of monochorionic twin pregnancies whereby the placenta is transferred to the pathology department for analysis. Exclusion Criteria: * Singleton, dichorionic and higher order pregnancies (e.g. triplet). * Fetus with known major congenital anomalies or aneuploidy
Where this trial is running
Birmingham, West Midlands
- Birmingham Women's and Children's NHS Foundation Trust — Birmingham, West Midlands, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Jack Hamer, MBChB — Birmingham Women's and Children's NHS Foundation Trust
- Study coordinator: Jack Hamer, MBChB
- Email: jack.hamer1@nhs.net
- Phone: 0121 472 1377
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Placenta, Monochorionic Twins, Anatomy