Placental characteristics in monochorionic twins
Official title: Placental Characteristics Within Monochorionic Twin Pregnancies: a Prospective Cohort Study.
Run by Birmingham Women's NHS Foundation Trust · NCT07124312 · Data updated 2026-11-12
This project will see how placental anatomy relates to outcomes for families with monochorionic twins by analyzing placentas after birth at a Birmingham NHS site.
Quick facts
| Study type | Observational |
|---|---|
| Sex | Women only |
| Enrollment | 65 (estimated) |
| Sponsor | Birmingham Women's NHS Foundation Trust Government |
| Locations | 1 site (Birmingham, West Midlands) |
| Status | Recruiting |
| Started | December 12, 2024 |
| Main results expected | January 1, 2027 |
| Study ends | February 1, 2027 |
| Registry record updated | August 15, 2025 |
| Trial ID | NCT07124312 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people pregnant with monochorionic twins who consent antenatally and deliver at the site such that the placenta can be transferred to the pathology department for analysis.
✕Probably not a fit
Patients with singleton, dichorionic, higher-order pregnancies, major fetal anomalies or aneuploidy, or those who do not deliver at the recruiting site are not eligible and would not benefit from this project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, single-site observational project will recruit people carrying monochorionic twin pregnancies during the antenatal period and obtain consent for placental analysis after delivery. All placentas transferred to the pathology department will be examined macroscopically and key anatomical features will be recorded. These placental findings will be compared with antenatal complications and perinatal outcomes for each twin pair. The goal is to build a comprehensive database to better understand how placental architecture may inform antenatal care.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor antenatal surveillance based on placental anatomy and potentially improve perinatal outcomes for monochorionic twins.
How similar studies have gone: Previous placental pathology studies have linked placental anatomy to outcomes in twin pregnancies, but a prospective, comprehensive UK cohort focusing on all monochorionic placentas at a single center is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: • All consecutive placentas of monochorionic twin pregnancies whereby the placenta is transferred to the pathology department for analysis. Exclusion Criteria: * Singleton, dichorionic and higher order pregnancies (e.g. triplet). * Fetus with known major congenital anomalies or aneuploidy
Where it's running
-
Birmingham Women's and Children's NHS Foundation Trust
Birmingham, West Midlands, United Kingdom Recruiting
Study contacts
- Principal investigator: Jack Hamer, MBChB — Birmingham Women's and Children's NHS Foundation Trust
- Study coordinator: Jack Hamer, MBChB
- Email: jack.hamer1@nhs.net
- Phone: 0121 472 1377
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.