Pilot return-to-work brain health program for stroke survivors
A Pilot Return-to-Work Cognitive Intervention After Stroke
This program tests a community-based brain health course run by neuropsychologists to help stroke survivors with mild cognitive problems return to work, with caregivers invited to participate.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 21 Years to 65 Years |
| Sex | All |
| Sponsor | National University of Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Trial ID | NCT07116187 on ClinicalTrials.gov |
What this trial studies
The trial delivers the Train-Your-Brain Stroke Recovery Programme in community settings, led by registered clinical neuropsychologists, to stroke survivors with mild cognitive impairment who are aiming to return to work. It uses a mixed-methods design combining feasibility and acceptability measures with pre- and post-intervention cognitive tests, vocational outcomes, and exploratory neuroplasticity biomarkers. Caregivers are included to support skill generalization and to capture psychosocial and functional effects. Key outcomes include cognitive performance, return-to-work status, fatigue, self-care, and measures of brain mechanism change.
Who should consider this trial
Good fit: Ideal candidates are community-dwelling adults aged 21–65 at least three months after stroke who meet criteria for mild cognitive impairment, can communicate in English, have no major psychiatric illness, and are aiming to return to or change work.
Not a fit: Patients with severe aphasia or physical disabilities that prevent participation, major psychiatric illness, non-English speakers, those not seeking return-to-work, or those with more advanced cognitive impairment are unlikely to benefit from this program.
Why it matters
Potential benefit: If successful, the program could improve cognitive function and increase the number of stroke survivors who can return to work, reducing long-term disability and caregiver strain.
How similar studies have performed: Previous cognitive rehabilitation programs after stroke have shown modest improvements in cognition and everyday function, but community-based return-to-work interventions targeting neuroplasticity are relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria (for stroke survivors): * Between 21 to 65 years old * Ability to provide informed consent * Consent to recording / photo-taking * Living in the community with at least three months after stroke * Looking to return to work or switch jobs after stroke * No significant aphasia or physical disability issues which will impede them from performing cognitive tasks in the interventions and assessments * No major psychiatric illnesses * Able to understand and converse in English * Score on MoCA ≤22 and/or SDMT ≤13 (for those educated ≤6 years) or SDMT ≤32 (for those educated \>6 years) * Meet criteria for Mild Cognitive Impairment based on the Vascular Dementia Battery Inclusion Criteria (for caregivers): * At least 21 years old * Ability to provide informed consent * Consent to recording / photo-taking * Staying with or having knowledge of the stroke survivor's functioning * No major psychiatric illnesses * Able to understand and converse in English Exclusion Criteria (for stroke survivors): * Less than 21 years old * More than 65 years old * Unable to provide informed consent * Refuse recording * Not living in the community and having less than three months after stroke * Significant aphasia or physical disability issues which will impede them from performing cognitive tasks in the interventions and assessments * Major psychiatric illnesses * Not able to understand and converse in English Exclusion Criteria (for caregivers): * Less than 21 years old * Unable to provide informed consent * Refuse recording * Not staying with or not having knowledge of the stroke survivor's functioning * Major psychiatric illnesses * Not able to understand and converse in English
Where this trial is running
Singapore
- National University of Singapore — Singapore, Singapore (Recruiting)
Study contacts
- Study coordinator: Yanhong Dong
- Email: nurdy@nus.edu.sg
- Phone: 65-65168686
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.