Physiotherapy using neuromodulation for women with persistent COVID-19 symptoms

Physiotherapy for Persistent Function by Superficial Neuromodulation

Not applicable Interventional Universidad Rey Juan Carlos · NCT05681455

This study tests if a new type of electrotherapy can help women with ongoing COVID-19 symptoms feel better, improve their quality of life, and sleep better.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment24 (estimated)
Ages18 Years to 60 Years
SexFemale
SponsorUniversidad Rey Juan Carlos Academic / other
Locations1 site (Alcorcón, Madrid)
Trial IDNCT05681455 on ClinicalTrials.gov

What this trial studies

This trial evaluates the effects of electrotherapy on pressure pain thresholds, fatigue, quality of life, and sleep quality in women suffering from Persistent COVID-19 Syndrome. Participants will be divided into two groups: one receiving active treatment and the other receiving a placebo. The study aims to assess improvements in symptoms over a 6-month and 1-year follow-up period, with a commitment to offer the placebo group treatment if positive results are observed. Secondary objectives include analyzing cardiac variability and cortisol levels pre- and post-treatment.

Who should consider this trial

Good fit: Ideal candidates are women who have experienced symptoms of Persistent COVID-19 for over a year and show signs of central sensitization.

Not a fit: Patients with previous surgeries, spinal trauma, or certain musculoskeletal diseases may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly improve the quality of life for women suffering from persistent COVID-19 symptoms.

How similar studies have performed: While this approach is innovative, similar studies have shown promise in treating chronic pain and fatigue syndromes, suggesting potential for success.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Women who have had symptoms of PC for more than one year.
* Signs of central sensitization.

Exclusion Criteria:

* Previous treatment with surgery.
* Previous spinal trauma.
* Whiplash.
* Pregnancy situation.
* Previous musculoskeletal disease (rheumatoid arthritis, sympathetic-reflex dystrophy, fibromyalgia).
* Pacemaker.
* Electric drug pump.
* Skin sensitivity alterations.
* Analgesic or anxiolytic drug treatment during the study.

Where this trial is running

Alcorcón, Madrid

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Post-Acute COVID-19 SyndromeDysautonomiaNeuromodulation
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.